Trial reportFrontiers in allergy2026
Safety of a novel oral immunotherapy approach in preschool children with single and multiple food allergies.
Trial report in Frontiers in allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Safety of a novel oral immunotherapy approach in preschool children with single and multiple food allergies.Frontiers in allergy · 2026Trial
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Oral immunotherapy (OIT) has emerged as a promising food allergy treatment with significant evidence of increased efficacy in preschool-aged children. However, current OIT protocols are generally burdensome and focus on single food allergies, while many children have multiple food allergies. A feasibility-oriented approach that minimizes the impact of therapy while allowing both single and multiple food allergy treatment is important to enhance accessibility for routine clinical practice. This study assesses the safety of a feasibility-oriented OIT protocol in preschool-aged children with single and multiple food allergies. Methods: This single-center prospective intervention study included children aged 9-24 months with proven food allergy (sensitization and a positive oral food challenge (OFC)). After a short dose escalation phase, children received one year of low-dose (300 mg protein/day) OIT, followed by an exit OFC four weeks after stopping therapy. Children with multiple food allergies received OIT for up to four allergens. Each allergen treatment is referred to as an OIT trajectory. Allergic dosing reactions (ADR) were recorded and classified using Sampson's severity score (grades I-V). Results: Between May 2019 and Oct 2022, 124 children (median age 17 months, IQR 11-20 months) started OIT for 189 food allergies. Peanut ( Conclusions: Our novel feasibility-oriented OIT protocol appears safe for various allergens and multifood OIT in preschool-aged children. Side effects were common but typically mild. However, they may lead to therapy discontinuation. Clinical Trial Registration: https://www.onderzoekmetmensen.nl/en/trial/49735, identifier NL7663.
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Registered trials
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