Evidence map›Paper›PMID 41705119›Full record

ArticleInternet interventions2026

Guided internet-based treatment for anxiety and depression in Norwegian primary care: a randomized non-inferiority effectiveness trial.

Marit Knapstad, Otto Robert Smith

Abstract read
In one paragraph

Article in Internet interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marit KnapstadDepartment of Health Promotion, Norwegian Institute of Public Health, Zander Kaaes gt. 7, 5015, Bergen, Norway.
Otto Robert SmithDepartment of Health Promotion, Norwegian Institute of Public Health, Zander Kaaes gt. 7, 5015, Bergen, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Meta-analyses suggest that therapist-guided internet-based cognitive behavioural therapy (iCBT) is as effective as face-to-face CBT for anxiety and depression, yet its non-inferiority in routine primary care settings is scarcely examined. We examined the non-inferiority of the therapist-guided program "Assisted self-help" (AS-iCBT) compared to treatment as usual within the Norwegian Prompt Mental Health Care (TAU-PMHC). Methods: A pragmatic, parallel-group, randomized controlled non-inferiority trial with 1:2 (AS-iCBT: TAU-PMHC) allocation was conducted. Participants ( Results: Both groups showed clinically significant reductions in PHQ-9 ( Conclusion: AS-iCBT did not meet the pre-defined criteria for non-inferiority compared to usual PMHC care for most outcomes. Nevertheless, AS-iCBT showed potential as a resource-efficient treatment option, requiring less therapist time while achieving clinically significant improvements. Further research should focus on optimizing its implementation, particularly for anxiety-related conditions.

Indexed as

AcceptabilityAnxietyDepressionGuided internet-based treatmentiCBTNon-inferiority trialPrimary care

Identifiers

PMID41705119
PMCPMC12907875

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.