ArticleTransplantation direct2026
A Whole-body Cooling Strategy in Uncontrolled Donation After Circulatory Death: Insights From a Porcine Ex Vivo Lung Perfusion Model.
Article in Transplantation direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Prolonged warm ischemia in uncontrolled donation after circulatory death (uDCD) potentially increases the risk of graft dysfunction in lung transplantation. To address this concern, a noninvasive, whole-body cooling approach was developed using a specialized liquid refrigerant at -21 °C. The aim of this study was to investigate whether this method reduces lung temperature and improves lung function in uDCD donors. Methods: Fifteen pigs were randomly assigned to 3 groups. In the study group (n = 5), the entire donor body was submerged in a basin containing a coolant of -21 °C, and chest compression was performed during 90 min of warm ischemia. In the sham group (n = 5), neither body cooling nor chest compression was performed during 90 min of warm ischemia. Lungs were evaluated by cellular ex vivo lung perfusion (EVLP) after 5 h of additional cold ischemia. Lungs in the donation after brain death (DBD) group (n = 5) were perfused after 1 h of cold ischemia. Results: Tracheal temperature decreased to 28.5 °C in the study group and remained at 38.1 °C in the sham group. Lungs in the study group showed higher transplant suitability with significantly higher PaO Conclusions: This novel cooling approach effectively reduced lung temperature during warm ischemia, resulting in improved lung function during EVLP. These data suggest that this method could mitigate ischemia-reperfusion injury in uDCD donors, expanding the donor lung pool.
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