ArticleJournal of bone oncology2026
Differential expression of CD74 and C1QB in jaw versus long bone osteosarcoma: Insights from animal models, public datasets and clinical cohorts.
Article in Journal of bone oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to investigate the differential expression of macrophage-related factors between jaw and long bone osteosarcoma, thereby providing potential candidates for future functional and mechanistic research. Methods: Twenty-four Sprague-Dawley (SD) rats were randomly divided into control, jaw osteosarcoma, and long bone osteosarcoma groups. UMR106 cells were implanted subcutaneously in nude mice, then tumors were transplanted into rat jaw and tibial bone marrow to establish osteosarcoma models. Bone changes were observed using Micro-CT, while histological changes were examined with H&E and Masson's trichrome staining. Transcriptome sequencing identified differentially expressed genes (DEGs), with the top three genes selected using Cytohubba software. Survival analysis was performed using the GEPIA database. A retrospective analysis was conducted on jaw osteosarcoma patients and long bone osteosarcoma patients from November 2014 to June 2023. Finally, immunohistochemical staining validated the expression levels of relevant proteins in both animal and clinical tissue samples. Results: Micro-CT revealed significant bone destruction in both osteosarcoma models. Histological analysis revealed high pleomorphism in osteosarcoma cells, predominantly spindle and polygonal shapes, with evident pathological mitosis. Transcriptome sequencing identified 414 DEGs, including the top three: Conclusion: The expression levels of CD74 and C1QB were significantly higher in jaw osteosarcoma than in long bone osteosarcoma, suggesting that this differential expression may have clinical relevance for patient survival and warrants further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.