Evaluating the Relationship Between Programmed Death Ligand-1 (Clone: 22C3), Anaplastic Lymphoma Kinase (D5F3), and C-ros Oncogene 1 (OT11A1) Expression in Lung Adenocarcinoma.

Kartavya K Verma, Amit Bugalia, Ajoy K Behera, Nighat Hussain

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In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Kartavya K VermaDepartment of Pathology, Shri Rawatpura Sarkar Institute of Medical Sciences and Research, Raipur, IND.

Amit BugaliaDepartment of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Raipur, IND.

Ajoy K BeheraDepartment of Pulmonary Medicine and Tuberculosis, All India Institute of Medical Sciences, Raipur, IND.

Nighat HussainDepartment of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Raipur, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective This study investigates the relationship between programmed death ligand-1 (PD-L1), anaplastic lymphoma kinase (ALK), and c-ros oncogene 1 (ROS1) expression in lung adenocarcinoma (ADC). Methods Sixty-two cases were analyzed for ALK, ROS1, and PD-L1 expression using immunohistochemistry. Statistical evaluations were performed using chi-square and Fisher's exact tests. Results Among the 62 cases, 24 (39%) were identified as PD-L1 positive, while four (6.45%) and three (4.84%) demonstrated ALK and ROS1 positivity, respectively, highlighting the molecular heterogeneity of lung adenocarcinoma. A significant association was observed between PD-L1 expression and the clinical stage of the disease (p = 0.048, df = 5,

Indexed as

anaplastic lymphoma kinase (alk)c-ros oncogene 1 (ros1)lung adenocarcinoma (adc)molecular oncologyprogrammed death ligand 1 (pd-l1)

Identifiers

PMID41704963

DOI10.7759/cureus.101737

PMCPMC12908612

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