ArticleFrontiers in aging neuroscience2026
Exploring biomechanical differences between brain-first and body-first Parkinson's disease subtypes using shear wave elastography: a pilot cross-sectional study.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This exploratory study aimed to investigate whether ultrasound shear wave elastography (SWE) could quantify rigidity in Parkinson's disease (PD) and assess potential biomechanical differences between the brain-first and body-first subtypes. Methods: Shear wave elastography was used to measure the Young's modulus (YM) and shear wave velocity (SWV) of the biceps brachii in 70 healthy controls (HCs) and 102 patients with PD (40 classified as body-first, 62 classified as brain-first based on RBDSQ criteria). Group comparisons were conducted using Results: Young's modulus and SWV values were significantly higher in PD patients than in HCs (all Conclusion: Shear wave elastography is a sensitive tool for quantifying rigidity in PD. This pilot study provides the first evidence of a significant difference in muscle biomechanical properties between PD subgroups classified according to current clinical criteria. While SWE shows promise as a supplementary biomarker, its integration with established subtyping markers (e.g., polysomnography, MIBG scintigraphy) in future multimodal and longitudinal studies is essential to determine its role in clinical subtyping.
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