Evidence map›Paper›PMID 41704900›Full record

ArticleKidney international reports2026

Access-Related Hand Dysfunction After Hemodialysis Access Placement.

Kyoungrae Kim, Trace Thome, Lauren Stone, Nicholas Vugman, Eric M Kunz, Samuel Alvarez, Qingping Yang, Kerri A O'Malley, Erik M Anderson, Brian Fazzone and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kyoungrae KimDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Trace ThomeDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Lauren StoneDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Nicholas VugmanDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Eric M KunzDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Samuel AlvarezDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Qingping YangDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Kerri A O'MalleyDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, University of Florida, Gainesville, Florida, USA.
Erik M AndersonDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, University of Florida, Gainesville, Florida, USA.
Brian FazzoneDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, University of Florida, Gainesville, Florida, USA.
Pavel MazirkaDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, University of Florida, Gainesville, Florida, USA.
Jesseca AntoineDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, University of Florida, Gainesville, Florida, USA.
Scott A BerceliDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, University of Florida, Gainesville, Florida, USA.
Terence E RyanDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Salvatore T ScaliDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, University of Florida, Gainesville, Florida, USA.

Funding

Impaired Mitochondrial Energetics is a Driver of Hemodialysis Access Related Hand DysfunctionR01HL148597 · NHLBI · UNIVERSITY OF FLORIDA · PI SCALI, SALVATORE T. · 2019 to 2023
$2.7M
NHLBI NIH HHS R01 HL148597
6 · The paper itself

Abstract

Introduction: Patients with chronic kidney disease (CKD) or end-stage kidney disease (ESKD) frequently experience access-related hand dysfunction (ARHD) following hemodialysis access placement, negatively impacting clinical outcomes and quality of life. Despite its prevalence, the mechanisms underlying ARHD remain poorly understood, and its impact on subsequent access maturation failure has not been well-characterized. Methods: We conducted a longitudinal study of 39 patients with CKD or ESKD undergoing hemodialysis access surgery. Functional assessments, including grip strength, finger pressure, patient-reported hand or arm disability, dexterity, and sensory testing were performed preoperatively and 6 weeks postoperatively. Brachioradialis muscle biopsies were analyzed for morphological changes, mitochondrial function, and transcriptomic profiles. Dialysis access maturation failure was evaluated at 6-month follow-up. Results: Six weeks after surgery, grip strength declined by 13.5 ± 19.4% ( Conclusion: In patients with CKD or ESKD, hemodialysis access surgery results in ARHD, which is associated with muscle atrophy, altered transcriptomic profiles, and higher incidence of access maturation failure. These findings underscore the need for early identification and targeted interventions to prevent ARHD and improve dialysis-access surgery outcomes.

Indexed as

access failurechronic kidney diseaseend-stage kidney diseasehand dysfunctionhemodialysis accessmuscle atrophy

Identifiers

PMID41704900
PMCPMC12906999

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.