Evidence map›Paper›PMID 41704889›Full record

ArticleFrontiers in neurology

Effect of pre-ICU aspirin use on neuroinflammation and outcomes in patients with sepsis-associated encephalopathy.

Zhenkun Xu, Qichao Yang, Hunian Li, Ting He

Abstract read
In one paragraph

Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhenkun Xu *Department of Emergency Medicine, Shiyan Renmin Hospital, Hubei, China.
Qichao Yang *Department of Emergency Medicine, Shiyan Renmin Hospital, Hubei, China.
Hunian LiDepartment of Emergency Medicine, Shiyan Renmin Hospital, Hubei, China.
Ting HeDepartment of Neurology, Shiyan Renmin Hospital, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the effect of pre-ICU aspirin use on neuroinflammation and prognosis in sepsis-associated encephalopathy (SAE) patients. Methods: Clinical data of SAE patients admitted to our ICU (Mar 2022-Feb 2025) were retrospectively analyzed. Patients were grouped based on pre-admission aspirin use: exposed ( Results: The exposed group had higher Vm, Vd, and Vs at all time points ( Conclusions: Pre-ICU aspirin use can improve cerebral hemodynamics, reduce neuroinflammation, and improve 60-day survival in SAE patients without increasing adverse reactions.

Indexed as

aspirincerebral hemodynamicsneuroinflammationprognosissepsis-related encephalopathy

Identifiers

PMID41704889
PMCPMC12908166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.