ArticleEndoscopy international open2026
Phase 1 trial of lavage cytology collected with endoscopic ultrasound-guided fine-needle aspiration for preoperative pancreatic cancer.
Article in Endoscopy international open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Peritoneal cytology in pancreatic cancer: a comprehensive review on prognostic stratification and clinical decision-making.Cancer metastasis reviews · 2026Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and study aims: Intraoperative peritoneal lavage cytology (CY) influences prognosis in pancreatic cancer, and positive findings may lead to aborted surgery. Staging laparoscopy is traditionally used when no distant metastases are evident. We developed a novel method to assess CY using endoscopic ultrasound (EUS) and conducted a Phase 1 trial to evaluate its safety. Patients and methods: This non-randomized, prospective Phase I1trial was conducted in three stages with safety monitoring after each stage. The study was approved by the institutional review board (2023-0-239) and registered (UMIN000052528). Nine patients with pancreatic ductal adenocarcinoma who were considering surgery were enrolled between September 2023 and August 2024. A 3F sheath was inserted into the upper abdomen under endoscopic and fluoroscopic guidance, followed by injection of 200 to 300 mL of saline. After postural adjustments and abdominal massage, transrectal EUS-fine-needle aspiration was used to aspirate pelvic fluid. Results: Median age was 68 years (range, 36-80); 77.8% were male. Resectability status: resectable/borderline/unresectable (considering conversion): 4/2/3. The procedure was successful in all cases, with a median aspirated volume of 32 mL (range, 10-125). No adverse events occurred, and all patients were discharged the next day. Conclusions: This novel EUS-guided lavage cytology method was safe and feasible. A Phase 2 trial is planned.
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