ArticleIJID regions2026
Adherence to perioperative antimicrobial prophylaxis in cancer surgeries: A single-center retrospective study from Oman.
Article in IJID regions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
Objectives: Surgical antimicrobial prophylaxis (SAP) is essential for preventing surgical site infections (SSIs), particularly in oncology patients. However, adherence to SAP guidelines globally remains inconsistent. This study evaluated adherence to SAP protocols at a tertiary oncology center and assessed associated factors with non-adherence and SSI outcomes. Methods: A retrospective review was conducted at Sultan Qaboos Comprehensive Cancer and Research Center (SQCCCRC) from August 2022 to July 2023. SAP prescriptions were evaluated for four criteria: antibiotic choice, weight-based dosing, re-dosing, and duration. Non-adherence to any of the four components considered non-adherent. Demographics, cancer type, surgical procedure, wound classification, procedure duration, SSIs, and microbiology results were extracted from patient records. We used bivariate analysis and multivariable logistic regression model to identify factors associated with non-adherence. The cumulative incidence of SSIs was also calculated. Results: Of the 261 surgeries reviewed, overall adherence to SAP protocols was 65%. Weight-based dosing adherence was highest (99.6%), while re-dosing adherence was lowest (80%). Univariate analyses showed non-adherence linked to higher patient weight ( Conclusions: The study found suboptimal overall adherence to SAP protocols, particularly in re-dosing practices. Targeted antimicrobial stewardship interventions are warranted to address these gaps and minimize infection risk, especially in high-risk oncology populations.
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