Evidence map›Paper›PMID 41704780›Full record

ArticleiScience2026

The succinate prodrug NV354 prevents brain lesions and late-stage motor dysfunction in mitochondrial complex I deficiency.

Meagan J McManus, Yi Zhu, Cesar Alves, Neha Kohli, Patricia Prada-Dacasa, Laura Sanchez-Benito, Elisenda Sanz, Irene Yee, Lozen Robinson, Malkah Sheldon and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Meagan J McManusResuscitation Science Center of Emphasis, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Yi ZhuResuscitation Science Center of Emphasis, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Cesar AlvesDivision of Neuroradiology, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Neha KohliResuscitation Science Center of Emphasis, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Patricia Prada-DacasaMitochondrial Neuropathology Laboratory, Institut de Neurociències and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Laura Sanchez-BenitoMitochondrial Neuropathology Laboratory, Institut de Neurociències and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Elisenda SanzMitochondrial Neuropathology Laboratory, Institut de Neurociències and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Irene YeeMitochondrial Medicine, Department of Clinical Sciences Lund, Lund University, BMC A13, Lund 221 84, Sweden.
Lozen RobinsonResuscitation Science Center of Emphasis, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Malkah SheldonResuscitation Science Center of Emphasis, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Walter J McHughResuscitation Science Center of Emphasis, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Abhay RanganathanResuscitation Science Center of Emphasis, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Jennie MengResuscitation Science Center of Emphasis, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Nina DuncanResuscitation Science Center of Emphasis, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Alvar GrönbergAbliva AB, Medicon Village, Lund 223 81, Sweden.
Douglas C WallaceCenter for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Sarah PielResuscitation Science Center of Emphasis, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Michael KarlssonDepartment of Neurosurgery, Rigshospitalet, Copenhagen, Denmark.
Steven J MossIsomerase Therapeutics Ltd, Chesterford Research Park, Cambridge CB10 1 XL, UK.
Lee WebsterIsomerase Therapeutics Ltd, Chesterford Research Park, Cambridge CB10 1 XL, UK.
Magnus J HanssonMitochondrial Medicine, Department of Clinical Sciences Lund, Lund University, BMC A13, Lund 221 84, Sweden.
Eskil ElmérMitochondrial Medicine, Department of Clinical Sciences Lund, Lund University, BMC A13, Lund 221 84, Sweden.
Johannes K EhingerMitochondrial Medicine, Department of Clinical Sciences Lund, Lund University, BMC A13, Lund 221 84, Sweden.
Albert QuintanaMitochondrial Neuropathology Laboratory, Institut de Neurociències and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Todd J KilbaughResuscitation Science Center of Emphasis, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.

Funding

Superoxide-sensitive radiotracer as a predictive biomarker of Parkinson's disease progressionR01NS114656 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI MCMANUS, MEAGAN JOY · 2020 to 2024
$2.6M
NINDS NIH HHS R01 NS114656
6 · The paper itself

Abstract

Leigh syndrome is a fatal pediatric neurodegenerative disease caused by mitochondrial dysfunction, which can be modeled in the

Indexed as

biochemistrybiological sciencesnatural sciencesneuroscience

Identifiers

PMID41704780
PMCPMC12907114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.