Evidence map›Paper›PMID 41704772›Full record

ArticleiScience2026

Activation of SNr GABA neurons drives liver-brain-eye axis dysfunction in hepatic encephalopathy.

Kenan Li, Zhenhua Wang, Shaoheng Li, Feifei Wu, Yunhu Bai, Shujiao Li, Changlei Zhu, Ziwei Ni, Shuai Zhang, Yousheng Wu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kenan LiNational Demonstrational Center for Preclinical Experimental Medicine, The Fourth Military Medical University, Xi'an, China.
Zhenhua WangDepartment of Gastrointestinal Surgery, 967 Hospital, Joint Logistics Support Force, PLA, Dalian, China.
Shaoheng LiDepartment of Ophthalmology, First Affiliated Hospital, The Fourth Military Medical University, Xi'an, China.
Feifei WuNational Demonstrational Center for Preclinical Experimental Medicine, The Fourth Military Medical University, Xi'an, China.
Yunhu BaiGeneral Surgery, 988 Hospital, Joint Logistics Support Force, PLA, Zhengzhou, China.
Shujiao LiNational Demonstrational Center for Preclinical Experimental Medicine, The Fourth Military Medical University, Xi'an, China.
Changlei ZhuNational Demonstrational Center for Preclinical Experimental Medicine, The Fourth Military Medical University, Xi'an, China.
Ziwei NiNational Demonstrational Center for Preclinical Experimental Medicine, The Fourth Military Medical University, Xi'an, China.
Shuai ZhangNational Demonstrational Center for Preclinical Experimental Medicine, The Fourth Military Medical University, Xi'an, China.
Yousheng WuNational Demonstrational Center for Preclinical Experimental Medicine, The Fourth Military Medical University, Xi'an, China.
Fei TianNational Demonstrational Center for Preclinical Experimental Medicine, The Fourth Military Medical University, Xi'an, China.
Nannan LiuNational Demonstrational Center for Preclinical Experimental Medicine, The Fourth Military Medical University, Xi'an, China.
Tao ChenAerospace Clinical Medicine Center, The Fourth Military Medical University, Xi'an, China.
Cailian RuanDepartment of Neurobiology, Yan'an University School of Medicine, Yan'an, China.
Zuoming ZhangAerospace Clinical Medicine Center, The Fourth Military Medical University, Xi'an, China.
Yanling YangDepartment of Hepatobiliary Surgery, Xi-Jing Hospital, The Fourth Military Medical University, Xi'an, China.
Yayun WangNational Demonstrational Center for Preclinical Experimental Medicine, The Fourth Military Medical University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic encephalopathy (HE) is frequently accompanied by visual dysfunction, yet the mechanisms underlying the liver-brain-eye axis remain unclear. We established mouse models of acute hepatic encephalopathy (AHE) using thioacetamide and chronic hepatic encephalopathy (CHE) using bile duct ligation, confirming hyperammonemia and visual impairment by electroretinogram (ERG) and visual evoked potentials (VEPs). Retinal analyses revealed preserved structure in AHE, whereas CHE induced significant thinning of the ganglion cell layer (GCL), inner nuclear layer (INL), and outer plexiform layer (OPL). Viral anterograde tracing identified aberrant activation of medial substantia nigra pars reticulata glutamate decarboxylase 2-positive (mSNr

Indexed as

Molecular neuroscienceMolecular physiologyNeuroanatomy

Identifiers

PMID41704772
PMCPMC12907090

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.