Evidence map›Paper›PMID 41704727›Full record

ArticleIJU case reports2026

Early Recognition of Immune-Related Hepatitis During Avelumab Maintenance Therapy for Urothelial Carcinoma.

Yuka Iwama, Tomoyasu Sano, Yuta Sano, Tomokazu Kimura, Yushi Naito, Satoshi Inoue, Kazuna Matsuo, Shohei Ishida, Yoshihisa Matsukawa, Shusuke Akamatsu

Abstract read
In one paragraph

Article in IJU case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuka IwamaDepartment of Urology Nagoya University Nagoya Aichi Japan.ORCID https://orcid.org/0009-0001-6005-9210
Tomoyasu SanoDepartment of Urology Nagoya University Nagoya Aichi Japan.
Yuta SanoDepartment of Urology Nagoya University Nagoya Aichi Japan.
Tomokazu KimuraDepartment of Urology Nagoya University Nagoya Aichi Japan.
Yushi NaitoDepartment of Urology Nagoya University Nagoya Aichi Japan.
Satoshi InoueDepartment of Urology Nagoya University Nagoya Aichi Japan.
Kazuna MatsuoDepartment of Urology Nagoya University Nagoya Aichi Japan.ORCID https://orcid.org/0000-0001-8574-2932
Shohei IshidaDepartment of Urology Nagoya University Nagoya Aichi Japan.ORCID https://orcid.org/0000-0002-9338-4781
Yoshihisa MatsukawaDepartment of Urology Nagoya University Nagoya Aichi Japan.ORCID https://orcid.org/0000-0001-7823-2600
Shusuke AkamatsuDepartment of Urology Nagoya University Nagoya Aichi Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Avelumab is recommended as maintenance therapy for advanced urothelial carcinoma after platinum chemotherapy; however, immune-related adverse events can be severe and refractory. Case Presentation: A 79-year-old male developed immune-related hepatitis during avelumab maintenance therapy following gemcitabine plus carboplatin for metastatic recurrent urothelial carcinoma. Despite discontinuation of avelumab and treatment with high-dose corticosteroids, mycophenolate mofetil, and plasma exchange, liver failure progressed, leading to death on day 106. Conclusion: Hepatic irAEs during avelumab therapy are rare but potentially fatal. Early recognition and aggressive multidisciplinary management are essential to improve outcomes.

Indexed as

avelumabdrug‐induced liver injuryimmune‐related hepatitisurothelial carcinoma

Identifiers

PMID41704727
PMCPMC12907570

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.