ArticleFrontiers in medicine2026
Teledermatology and face-to-face pathways for basal cell carcinoma diagnosis in a southern European cohort: a comparative histopathologic analysis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Teledermatology has expanded markedly in the post-pandemic era; however, its impact on the histopathologic presentation of basal cell carcinoma (BCC) remains insufficiently characterized. Tumor depth and histologic subtype are key prognostic factors and may differ according to diagnostic pathway. Methods: We conducted a retrospective observational study at a tertiary referral hospital in southern Europe, including all histologically confirmed BCCs diagnosed in 2019 through face-to-face dermatology and in 2022 through teledermatology. A total of 486 tumors were analyzed (201 face-to-face; 285 teledermatology). Histologic subtypes (superficial, nodular, micronodular, sclerodermiform) were examined individually and grouped into non-aggressive (superficial/nodular) versus aggressive (micronodular/sclerodermiform) categories. Statistical analyses included Welch's Results: Mean tumor depth was significantly lower in the teledermatology cohort (1.67 mm vs. 2.51 mm; Conclusion: Teledermatology was associated with the diagnosis of significantly shallower BCCs, even across subtypes, supporting its role in facilitating earlier histologic detection. Subtype differences were pathway-specific but did not fully account for the depth disparity. These findings highlight teledermatology as an effective diagnostic route for timely identification of BCC in contemporary clinical practice.
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