Evidence map›Paper›PMID 41704661›Full record

ReviewBiofilm2026

Beyond the germ: Rethinking implant-related infections as a host-microbiota-biomaterial ecosystem.

D C Coraça-Huber, C Spiegel, B F Moraes, R Arora

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biofilm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

D C Coraça-HuberResearch Laboratory for Biofilms and Implant Associated Infections (BIOFILM LAB), Department of Orthopaedics and Traumatology, Medical University of Innsbruck, Müllerstraße 44, 6020, Innsbruck, Austria.
C SpiegelResearch Laboratory for Biofilms and Implant Associated Infections (BIOFILM LAB), Department of Orthopaedics and Traumatology, Medical University of Innsbruck, Müllerstraße 44, 6020, Innsbruck, Austria.
B F MoraesDepartmento de Odontologia Restauradora, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Avenida Limeira 901, CEP: 13414-903, Piracicaba, SP, Brazil.
R AroraResearch Laboratory for Biofilms and Implant Associated Infections (BIOFILM LAB), Department of Orthopaedics and Traumatology, Medical University of Innsbruck, Müllerstraße 44, 6020, Innsbruck, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implant-related infections remain one of the most challenging complications in modern medicine, often leading to implant failure, revision surgery, significant patient morbidity and high rate of patient mortality. Traditionally framed within the germ theory paradigm, their pathogenesis has been attributed primarily to microbial contamination and biofilm formation. However, growing evidence reveals a far more complex picture in which infection susceptibility emerges from the dynamic interplay between

Indexed as

BiofilmColonization resistanceDetoxificationGerm theoryHost–microbiota–biomaterial interactionsImplant-related infectionOxidative stressSystems biologyTerrain theory

Identifiers

PMID41704661
PMCPMC12907239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.