The influence of ocular parameters on intraocular pressure values measured by different devices and the development of an optimized prediction model in a myopic population.

Objective: To investigate the associations between ocular parameters-mean keratometry (Km), spherical equivalent (SE), central corneal thickness (CCT), axial length (AL), corneal hysteresis (CH), and corneal resistance factor (CRF)-and intraocular pressure (IOP) measurements obtained by non-contact tonometry (IOP Methods: This study included 64 patients (128 eyes). All participants underwent comprehensive ocular examinations (CCT, AL, SE, Km, CH, and CRF) and IOP measurements using multiple tonometers. Pearson correlation and multiple linear regression analyses were employed to identify key influencers on IOP readings. An optimized prediction model was subsequently developed using NCT, CCT, CH, and CRF as independent variables, and its goodness-of-fit was evaluated. Results: Age, AL, Km, IOP Conclusions: DCT measurements were less influenced by CCT, CH, and CRF, supporting their potential reliability for IOP assessment in patients with myopia. The optimized prediction model based on multiple regression analysis was able to predict DCT values to some extent, thereby reducing the influence of corneal biomechanical properties on IOP measurement. However, the model requires further validation and refinement in studies with larger sample sizes.