Evidence map›Paper›PMID 41704558›Full record

ArticleFrontiers in bioengineering and biotechnology2026

Protective effect of a novel hydrogel loaded with CM-UCMSCs on vitrified-thawed ovaries during in vitro culture.

Quan Wen, Li Zhao, Ting Wang, Mingjie Bao, Yan Ling, Si Qian, Yixiao Dou, Yabin Lin, Liqun Wang, Gorbachev Dmitrii and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Quan Wen *Obstetrics and Reproductive Health Department, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
Li Zhao *Medical Department, Shangrao Senior Technical School, Shangrao, Jiangxi, China.
Ting WangDepartment of Reproductive Health, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, China.
Mingjie BaoObstetrics and Reproductive Health Department, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
Yan LingObstetrics and Reproductive Health Department, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
Si QianDepartment of Clinical Medicine, Nanchang University, Nanchang, Jiangxi, China.
Yixiao DouDepartment of Clinical Medicine, Nanchang University, Nanchang, Jiangxi, China.
Yabin LinDepartment of Clinical Medicine, Nanchang University, Nanchang, Jiangxi, China.
Liqun WangDepartment of Clinical Medicine, Nanchang University, Nanchang, Jiangxi, China.
Gorbachev DmitriiGeneral hygiene department, Samara state medical university, Samara, Russia.
Irina KurzinaLaboratory of Chemical Technology, National Research Tomsk State University, Tomsk, Russia.
Yuan ZhuObstetrics and Reproductive Health Department, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian tissue cryopreservation and transplantation (OTCT) is an important fertility preservation method for female cancer patients; however, its efficacy is limited by post-transplantation ischemia-reperfusion injury, leading to oxidative stress, apoptosis, and fibrosis that impair ovarian reserve and graft function. Mesenchymal stem cell-conditioned medium shows therapeutic potential through paracrine actions, but clinical use is restricted by relatively limited antioxidant capacity and delivery challenges. To address this, an antioxidant-enriched hydrogel (PG-gel) was developed from N-acetylcysteine-modified gelatin and poly (ethylene glycol) succinimidyl succinate, loaded with conditioned medium from umbilical cord mesenchymal stem cells (CM-UCMSCs). This study evaluated the efficacy of PG-gel in protecting vitrified-thawed ovarian tissue during

Indexed as

antioxidanthydrogelOTCTumbilical cord mesenchymal stem cellsvitrified-thawed ovaries

Identifiers

PMID41704558
PMCPMC12907395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.