ArticleHemaSphere2026
Dissecting clonal hematopoiesis in the myeloid compartment of chronic lymphocytic leukemia and Richter transformation.
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Article in HemaSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5citing papers in PubMed
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Who cites it
5 citing papers in PubMed.
- To Treat or Not to Treat: Navigating Early-Stage CLL in the Era of Targeted Therapy.European journal of haematology · 2026Review
- Beyond Frailty Scores: Unmet Needs and Tailored Treatment Strategies in Patients With Chronic Lymphocytic Leukemia Aged ≥ 80 Years.European journal of haematology · 2026Review
- Integrative Transcriptomic and Functional Analysis of PKMYT1 Reveals a Potential Therapeutic Target in Chronic Lymphocytic Leukemia.Hematological oncology · 2026Article
- Clonal hematopoiesis dynamics influences long-term outcomes of follicular lymphoma: Results from FIL FOLL12 trial.HemaSphere · 2026Article
- Impact of high-fat Western diet on chronic lymphocytic leukemia disease progression and gut microbiome profile in Eµ-TCL1 mice.Frontiers in oncology · 2026Article
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Authors and funding
46 authors.
Chiara CosentinoDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Samir MouhssineDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Antonella ZucchettoClinical and Experimental Onco-Hematology Unit Centro di Riferimento Oncologico di Aviano (CRO), IRCCS Aviano Italy.
Ilaria RomanoLaboratory of Experimental Hematology Institute of Oncology Research Bellinzona Switzerland.ORCID https://orcid.org/0000-0001-5720-9807
Matin SalehiLaboratory of Experimental Hematology Institute of Oncology Research Bellinzona Switzerland.
Luca Vincenzo CappelliHematology, Department of Translational and Precision Medicine "Sapienza" University Rome Italy.
Fabio IannelliDivision of Hematopathology IEO European Institute of Oncology IRCCS Milano Italy.
Mohammad AlmasriDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Nawar MaherDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Lorenzo FumagalliDivision of Hematopathology IEO European Institute of Oncology IRCCS Milano Italy.
Deborah CardinaliHematology, Department of Translational and Precision Medicine "Sapienza" University Rome Italy.
Andrea VisentinHematology Unit Azienda Ospedale Università Padova Italy.ORCID https://orcid.org/0000-0003-0271-7200
Jana NabkiDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Luca CividiniDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Bashar Al DeebanDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Milena LazzaroDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Francesca MaiellaroDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Annalisa GaglioClinical and Experimental Onco-Hematology Unit Centro di Riferimento Oncologico di Aviano (CRO), IRCCS Aviano Italy.
Francesca PerutelliA.O.U. Città della Salute e della Scienza di Torino e Dipartimento di Biotecnologie Molecolari e Scienze per la Salute Università di Torino Torino Italy.ORCID https://orcid.org/0000-0002-7538-9626
Valentina GriggioA.O.U. Città della Salute e della Scienza di Torino e Dipartimento di Biotecnologie Molecolari e Scienze per la Salute Università di Torino Torino Italy.
Riccardo DondolinDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Matteo BelliaDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Maura NicolosiHematology Division A.O.U. Città della Salute e della Scienza di Torino Torino Italy.
Silvia RasiDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Eleonora SecomandiDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Valeria CaneparoCenter for Translational Research on Autoimmune & Allergic Diseases - CAAD Università del Piemonte Orientale Novara Italy.
Abdurraouf Mokhtar MahmoudDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Clara DeambrogiDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Sreekar KogilaDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Joseph GhanejDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Mohammad Reshad NawabiDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Ilaria Del GiudiceHematology, Department of Translational and Precision Medicine "Sapienza" University Rome Italy.
Elisa AlbiDivision of Experimental Oncology IRCCS Ospedale San Raffaele Milano Italy.
Candida VitaleA.O.U. Città della Salute e della Scienza di Torino e Dipartimento di Biotecnologie Molecolari e Scienze per la Salute Università di Torino Torino Italy.
Lydia ScarfòDivision of Experimental Oncology IRCCS Ospedale San Raffaele Milano Italy.
Marta CosciaDepartment of Medicine and Surgery University of Insubria Varese Italy.
Livio TrentinHematology Unit Azienda Ospedale Università Padova Italy.
Stefano PileriDivision of Hematopathology IEO European Institute of Oncology IRCCS Milano Italy.
Paolo GhiaDivision of Experimental Oncology IRCCS Ospedale San Raffaele Milano Italy.ORCID https://orcid.org/0000-0003-3750-7342
Roberto ChiarleDivision of Hematopathology IEO European Institute of Oncology IRCCS Milano Italy.
Valter GatteiClinical and Experimental Onco-Hematology Unit Centro di Riferimento Oncologico di Aviano (CRO), IRCCS Aviano Italy.
Lodovico Terzi di BergamoLaboratory of Experimental Hematology Institute of Oncology Research Bellinzona Switzerland.
Davide RossiLaboratory of Experimental Hematology Institute of Oncology Research Bellinzona Switzerland.
Robin FoàHematology, Department of Translational and Precision Medicine "Sapienza" University Rome Italy.
Gianluca GaidanoDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.
Riccardo MoiaDivision of Hematology, Department of Translational Medicine Università del Piemonte Orientale and AOU Maggiore della Carità di Novara Novara Italy.ORCID https://orcid.org/0000-0001-7393-1138
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical and biological significance of clonal hematopoiesis (CH) has not been investigated in the myeloid compartment of chronic lymphocytic leukemia (CLL). By studying 488 newly diagnosed CLL through CAPP-seq using a 28-gene panel on granulocyte genomic DNA (gDNA), CH occurred in 231 (47.3%) patients. Cell sorting of cases that never developed Richter transformation (RT) confirmed that CH mutations, including CH-related
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