Evidence map›Paper›PMID 41704486›Full record

ReviewFrontiers in endocrinology2026

Hashimoto's thyroiditis: from pathogenesis to clinical management.

Linghui Wang, Xi Zhu, Shuting Xu, Bin Zhou, Yong Wu, Zhouting Li, Yanjie Zhao, Shuhui Li, Feng Cheng, Lei Zhu

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07571681 (Colchicine as a Novel Anti-Inflammatory Strategy in Autoimmune and Subacute Thyroiditis), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07571681 phase2 / phase3recruitingnot on this map

Colchicine as a Novel Anti-Inflammatory Strategy in Autoimmune and Subacute Thyroiditis: A Prospective Three-Arm Randomized Controlled Trial

TypeinterventionalSponsorMansoura UniversityRan2026 to 2027Enrolled300ConditionsHashimoto Thyroiditis, Subacute Thyroiditis, ThyroiditisArmscolchicine, Prednisolone, NSAID
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Linghui Wang *Graduate Joint Training Base of Zhejiang Chinese Medical University (Lishui Joint Training Base - Lishui Municipal Central Hospital), Hangzhou, Zhejiang, China.
Xi Zhu *Department of Head and Neck Surgery, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang, China.
Shuting XuDepartment of Head and Neck Surgery, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang, China.
Bin ZhouDepartment of Head and Neck Surgery, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang, China.
Yong WuDepartment of Head and Neck Surgery, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang, China.
Zhouting LiDepartment of Head and Neck Surgery, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang, China.
Yanjie ZhaoDepartment of Head and Neck Surgery, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang, China.
Shuhui LiDepartment of Head and Neck Surgery, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang, China.
Feng ChengDepartment of Head and Neck Surgery, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang, China.
Lei ZhuDepartment of Head and Neck Surgery, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hashimoto's thyroiditis (HT) is a chronic autoimmune thyroiditis characterized by thyroid-specific autoantibodies (TPOAb, TGAb) positivity and lymphocytic infiltration, and is a major cause of hypothyroidism in iodine-sufficient regions. Epidemiological data show a significant increase in the prevalence of HT, which is about four times more common in adult women than in men. The pathogenesis of HT involves a complex interaction of genetic susceptibility, environmental factors, and immune regulation. Its clinical diagnosis is mainly based on serological tests (TPOAb/TGAb) and thyroid ultrasound features. The current treatment of Hashimoto's is based on levothyroxine (T4) replacement. This article presents a narrative review of the pathogenesis, status, and challenges of treatment of HT to provide a theoretical basis for optimizing clinical practice and basic research.

Indexed as

Hashimoto DiseaseAutoantibodiesHumansThyroxineAutoantibodiesThyroxineautoimmunityHashimoto’s thyroiditishypothyroidismimmunomodulationthyroglobulin antibodythyroid peroxidase antibody

Identifiers

PMID41704486
PMCPMC12907336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.