ArticleJBMR plus2026
Inflammatory cytokines secreted from senescent periodontal ligament cells influence the osteocyte network in alveolar bone.
Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Immunosenescence and Bone Homeostasis: From Mechanisms of Homeostasis Disruption to Therapeutic Opportunities in Age-Related Skeletal Disorders.International journal of molecular sciences · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rate of orthodontic tooth movement slows with age, likely due to changes in alveolar bone remodeling. However, the underlying mechanisms remain poorly understood. Osteocytes (OCys), which form the lacunar-canalicular network (LCN), play a key role in bone metabolism; however, the effects of aging on the alveolar LCN are still unclear. This study aimed to clarify age-related alterations in the LCN of alveolar bone and their underlying mechanisms. The LCN was visualized using Ploton silver staining, revealing a significant reduction in 16-mo-old C57BL/6J mice compared to 2-mo-old mice. The number of OCys, as well as the number and length of canaliculi per OCy, decreased significantly with age. These reductions were consistent in both sexes. Periodontal ligament cells (PDLCs) from aged mice showed increased expression of the senescence marker p16
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