ArticleTH open : companion journal to thrombosis and haemostasis2026
Reduced- Compared with Standard-Dose Direct Oral Anticoagulant for Extended Treatment of Venous Thromboembolism: A Systematic Review and Meta-Analysis.
Article in TH open : companion journal to thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Introduction: Reduced-dose direct oral anticoagulants (DOACs) may provide similar efficacy with less bleeding than standard dose for extended venous thromboembolism (VTE) treatment. It is unclear whether standard doses are preferable in certain subgroups. Methods: We systematically searched MEDLINE, EMBASE, EMCARE, and Cochrane Central Register of Controlled Trials (CENTRAL) for randomized trials comparing reduced- with standard-dose DOACs for extended VTE treatment (registration number: INPLASY202550061). Outcomes included recurrent VTE, major bleeding, clinically relevant non-major bleeding (CRNMB), and mortality. Results: Five trials (8,781 patients) were included. Reduced-dose DOACs (apixaban 2.5 mg twice daily or rivaroxaban 10 mg once daily, Conclusion: For extended VTE treatment, reduced-dose DOACs have a similar risk of recurrent VTE and a lower risk of major and CRNMB compared to standard dose, including high-risk patients. A potential interaction with sex warrants further investigation.
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