ArticleRSC advances2026
Colchicine-cinnamic acid hybrids with potent anticancer activities: synthesis,
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer represents a critical global health burden, with the clinical application of many chemotherapeutic agents constrained by limited efficacy and significant toxicity. Colchicine, a tubulin-targeting agent, exhibits potent anticancer activity but has a narrow therapeutic window. Conversely, natural cinnamic acid and its derivatives are safe but lack strong antitumor potency and specific targets. To resolve this "potency-toxicity" paradox, a series of colchicine-cinnamic acid hybrids (B1-B12) were designed and synthesized
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.