ArticleRSC advances2026
Structural, electronic and bioactive profiling of a 2'-hydroxychalcone-Ag composite: a DFT-supported biomedical study on anticancer, antioxidant and antibacterial activities.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Biocompatible and biologically active nanomaterials are currently in demand. This work presents the synthesis of the medicinally significant fluorophore 2'-hydroxychalcone and its subsequent composite with silver nanoparticles (chal-AgNPs) and their characterization using experimental and theoretical techniques and applications. The active organic functional groups present in the chalcone functioned as reducing and stabilizing agents in the composite with AgNPs by solution chemistry method. FESEM reveals spherically shaped and uniformly scattered nanoparticles with an average diameter of 70 nm. X-ray diffraction (XRD) patterns of chalcone-mediated AgNPs confirmed the existence of spherical AgNPs with a crystallite size of 46 nm in a face-centered cubic crystal structure. The surface plasmon resonance of AgNPs was observed at 493 nm in the absorption spectrum. The surface adsorption of chal-AgNPs was further validated by mixing pre-synthesized AgNPs prepared by sodium borohydride reduction with chalcone and real-time monitoring of the UV-visible spectrum. The
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