ArticleFrontiers in psychology2026
Latent profiles of childhood trauma in bipolar disorder: associations with objective and subjective cognitive functioning and quality of life.
Article in Frontiers in psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Childhood trauma is associated with a more severe clinical course in bipolar disorders; however, the latent profiles of childhood trauma and their differential impacts on cognitive functioning and quality of life remain underexplored. Methods: Using latent profiles analysis, 275 bipolar patients were categorized into distinct trauma profiles based on Childhood Trauma Questionnaire scores. The characteristics of sociodemographic, clinical, pharmacological and biochemical variables, as well as objective and subjective cognitive functioning, and quality of life, were compared across profiles and with 63 healthy controls. Results: Three distinct profiles emerged: high trauma ( Discussion: This study highlights multiple childhood trauma profiles in bipolar disorder. Findings reveal that trauma and neglect significantly influence diverse functional and clinical outcomes in bipolar disorder. Further research is crucial to elucidate their impact mechanisms.
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