Evidence map›Paper›PMID 41704374›Full record

ArticleACS medicinal chemistry letters2026

Design and Synthesis of Actin-Targeting 10-Phenoxy Cytochalasan Analogues: Balancing Cytotoxicity and Migrastatic Activity.

Žaneta Javorská, Tereza Volfová, Johan Faivre, Wim Dehaen, Silvie Rimpelová, Magdaléna Labíková, Daniel Rösel, Jan Brábek, Pavla Perlíková

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In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Žaneta JavorskáDepartment of Organic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague, Czechia.ORCID https://orcid.org/0000-0001-6894-767X
Tereza VolfováDepartment of Cell Biology, BIOCEV, Faculty of Science, Charles University, Průmyslová 595, 252 50 Vestec, Prague West Czechia.
Johan FaivreDepartment of Organic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague, Czechia.
Wim DehaenDepartment of Organic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague, Czechia.ORCID https://orcid.org/0000-0001-6979-5508
Silvie RimpelováDepartment of Biochemistry and Microbiology, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague, Czechia.ORCID https://orcid.org/0000-0002-3008-1396
Magdaléna LabíkováDepartment of Organic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague, Czechia.ORCID https://orcid.org/0009-0004-8900-6675
Daniel RöselDepartment of Cell Biology, BIOCEV, Faculty of Science, Charles University, Průmyslová 595, 252 50 Vestec, Prague West Czechia.
Jan BrábekDepartment of Cell Biology, BIOCEV, Faculty of Science, Charles University, Průmyslová 595, 252 50 Vestec, Prague West Czechia.
Pavla PerlíkováDepartment of Organic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague, Czechia.ORCID https://orcid.org/0000-0002-8500-0493

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytochalasans are actin polymerization inhibitors with potent migrastatic activity, but their potential therapeutic use is limited by their cytotoxicity. Here, we describe a modular late-stage approach that introduces unprecedented 10-phenoxy substituents into the cytochalasan scaffold via a Mitsunobu reaction. A series of ten 10-phenoxycytochalasan analogues was synthesized and evaluated for actin polymerization inhibition, migrastatic activity, and cytotoxicity (BLM, MRC-5, and HaCaT). At 10 μM concentration, several 7-hydroxy-10-phenoxycytochalasans (

Indexed as

actin polymerization inhibitorscancer cell invasivenessCytochalasancytotoxicitymigrastatics

Identifiers

PMID41704374
PMCPMC12907919

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.