Evidence map›Paper›PMID 41704343›Full record

ArticleFrontiers in genetics2026

Cross-trait genetic enrichment between GERD and psychiatric disorders in East Asian populations.

Zhihao Gao, Xianjin Wang, Zekun Liu, Fen Hu, Yidi Zhou, Kalim Ullah, Ruiwei Wang, Meng Zhang, Xiao Chang, Yongsen Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhihao Gao *First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Xianjin Wang *College of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, Shandong, China.
Zekun LiuCollege of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, Shandong, China.
Fen HuCollege of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, Shandong, China.
Yidi ZhouSchool of Pharmacy, Yantai University, Yantai, Shandong, China.
Kalim UllahCollege of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, Shandong, China.
Ruiwei WangDepartment of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Meng ZhangCollege of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, Shandong, China.
Xiao ChangCollege of Medical Information and Artificial Intelligence, Shandong First Medical University, Jinan, Shandong, China.
Yongsen WangFirst Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastroesophageal reflux disease (GERD) exhibits significant epidemiological comorbidity with psychiatric disorders, yet their shared genetic architecture remains poorly characterized in East Asian populations. Leveraging ancestry-specific genome-wide association study (GWAS) summary statistics from East Asian cohorts, we employed linkage disequilibrium score regression and conditional false discovery rate (condFDR) approaches to investigate cross-trait genetic enrichment between GERD and major psychiatric disorders, including major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BIP). We identified significant genetic correlations between GERD and both MDD (r

Indexed as

conditional false discovery ratecross-trait enrichmentgastroesophageal reflux diseasegenetic correlationpsychiatric disorders

Identifiers

PMID41704343
PMCPMC12908923

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.