Evidence map›Paper›PMID 41704315›Full record

ArticleFrontiers in microbiology2026

Emergence and genomic characterization of hypervirulent ST23/K1

Matej Bezdicek, Marketa Jakubickova, Viktoria Bitusikova, Ema Holubova, Helena Vitkova, Iva Kocmanova, Ivana Vitkova, Lenka Zdrazilova Dubska, Martina Lengerova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matej BezdicekDivision of Clinical Microbiology and Immunology, Department of Laboratory Medicine, University Hospital Brno, Brno, Czechia.
Marketa JakubickovaDivision of Clinical Microbiology and Immunology, Department of Laboratory Medicine, University Hospital Brno, Brno, Czechia.
Viktoria BitusikovaDivision of Clinical Microbiology and Immunology, Department of Laboratory Medicine, University Hospital Brno, Brno, Czechia.
Ema HolubovaDivision of Clinical Microbiology and Immunology, Department of Laboratory Medicine, University Hospital Brno, Brno, Czechia.
Helena VitkovaDepartment of Biomedical Engineering, Faculty of Electrical Engineering and Communication, Brno University of Technology, Brno, Czechia.
Iva KocmanovaDivision of Clinical Microbiology and Immunology, Department of Laboratory Medicine, University Hospital Brno, Brno, Czechia.
Ivana VitkovaDivision of Clinical Microbiology and Immunology, Department of Laboratory Medicine, University Hospital Brno, Brno, Czechia.
Lenka Zdrazilova DubskaDivision of Clinical Microbiology and Immunology, Department of Laboratory Medicine, University Hospital Brno, Brno, Czechia.
Martina LengerovaDivision of Clinical Microbiology and Immunology, Department of Laboratory Medicine, University Hospital Brno, Brno, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hypervirulent Methods: From 2017 to 2025, 570 Results: The Czech K1/ST23 KP population exhibited high virulence uniformity (95/96 isolates scoring 9/9) without evidence of a single-clone outbreak, instead forming multiple phylogenetic lineages consistent with recurrent introductions. Eighty-three isolates carried pLVPK-like virulence plasmids; however, structural plasticity was prominent. The Conclusion: K1/ST23 KP circulating in the Czech Republic is highly virulent yet genomically diverse, driven by active plasmid exchange, insertion-sequence-mediated chromosomal integration, and emerging virulence-resistance fusion plasmids. Although carbapenemase genes were absent, ESBL determinants and transmissible virulence loci indicate strong evolutionary potential toward MDR-hvKp. Continuous genomic surveillance and early intervention strategies are essential to mitigate future clinical impact.

Indexed as

hypervirulentKlebsiella pneumoniaelong-read sequencingmultidrug resistanceplasmidST23whole genome sequencing

Identifiers

PMID41704315
PMCPMC12907322

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.