Evidence map›Paper›PMID 41704298›Full record

ArticleMaterials today. Bio2026

Living bacterial reactor potently activates tumor immunogenic ferroptosis via cysteine depletion and photothermal therapy.

Mengen Guo, Wenjie Xu, Yanjin Peng, Yucheng Tang, Xinyan Hao, Tiantian Tang, Xinying Liu, Hai Huang, Ruyue Han, Junyong Wu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mengen GuoDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Wenjie XuDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Yanjin PengDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Yucheng TangDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Xinyan HaoDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Tiantian TangDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Xinying LiuDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Hai HuangDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Ruyue HanDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Junyong WuDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Daxiong XiangDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial combination therapy offers immense promise for treating aggressive "cold" solid tumors, such as triple-negative breast cancer (TNBC). However, the clinical translatability of traditional genetic engineering is often hampered by operational complexity and genetic instability. Here, we developed A-SPB-a non-genetically engineered, multi-functional living bioreactor based on

Indexed as

Cysteine depletionFerroptosisImmunotherapyLiving bacteriaPhotothermal therapy

Identifiers

PMID41704298
PMCPMC12907108

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.