ArticleEuropean journal of neurology2026
Real-World Use of Cenobamate in Paediatric Drug-Resistant Epilepsy: Long-Term Efficacy, Safety, and Co-Medication Adjustment.
Article in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Real-World Use of Cenobamate in Paediatric Drug-Resistant Epilepsy: Long-Term Efficacy, Safety, and Co-Medication Adjustment.European journal of neurology · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe evaluated the real-world efficacy, tolerability, treatment retention, and quality-of-life effects of cenobamate in paediatric drug-resistant epilepsy.
methodsWe retrospectively studied 78 paediatric patients with drug-resistant epilepsy treated with cenobamate for ≥ 3 months at a tertiary epilepsy centre. We assessed seizure frequency, adverse effects, cognitive/behavioural outcomes, and changes in concomitant antiseizure medications. The primary efficacy endpoint was a ≥ 50% reduction in seizure frequency. We assessed safety through reported adverse events and clinical improvement using the Clinical Global Impression-Improvement (CGI-I) scale. We used Kaplan-Meier analyses to assess responder rates and treatment retention over 18 months.
resultsA ≥ 50% seizure reduction was achieved in 67.9% of patients including 6.4% who became seizure-free. Polytherapy was simplified in 38% overall and in 56.6% of responders. Adverse events occurred in 43.6% of patients, were mostly mild, and led to discontinuation in only one patient (1.3%). CGI-I indicated clinical improvement in 24.4%. Kaplan-Meier analysis showed sustained response in 93% of initial responders at 18 months. Treatment retention remained high: 94.7% at 3 months, 89.6% at 12 months, and 86.8% at 18 months. Median follow-up was 12 months (range 3-18), with 60.3% followed for ≥ 12 months and 41% for the full 18 months.
conclusionsOur study confirms and extends recent evidence on the efficacy and favourable tolerability of cenobamate in paediatric drug-resistant epilepsy. We observed functional improvements and polytherapy simplification, suggesting broader therapeutic benefits. These findings warrant prospective validation in specific paediatric epilepsy syndromes and may help support regulatory approval for paediatric use.
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