ArticleClinical and experimental dental research2026
The Effect of Free and Nanoliposomal Curcumin on the Viability and Acid Production of Single-Species (Streptococcus mutans) and Polymicrobial Biofilms.
Article in Clinical and experimental dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Curcumin-Based Nanoformulations for Oral Health: Mechanistic Insights, Antimicrobial Efficacy, and Future Clinical Perspectives.Biomedicines · 2026Review
- The Effect of Free and Nanoliposomal Curcumin on the Viability and Acid Production of Single-Species (Streptococcus mutans) and Polymicrobial Biofilms.Clinical and experimental dental research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectivesDental caries is a global health concern caused by the formation of cariogenic biofilms and their acid production. While various approaches have been tried, the rise of antibiotic-resistant microorganisms necessitates safer and more effective antimicrobial solutions. Natural substances can be safe and effective alternatives in controlling dental biofilms and preventing tooth decay. In this study, the effect of free and nanoliposomal curcumin on oral biofilms (single species and polymicrobial) was investigated. MATERIAL AND
methodsCurcumin nanoliposomes were prepared using the thin layer hydration method, and their characteristics (size, zeta potential, and release of curcumin from liposomes) were evaluated. An Active Attachment model was used to compare the effect of free and nanoliposomal curcumin in the single-species (Streptococcus mutans) and poly microbial biofilms and amount of acid production by them.
resultsAccording to the obtained results, the diameter of liposomes was 98.83 ± 2.89 nm, and the release of curcumin from liposomes was less than 50% after 24 h. The MIC of free and non-liposomal curcumin against S. mutans was 250 and 222 μg/mL, respectively. Nanoliposomal curcumin reduced the number of cells in polymicrobial and single-species biofilms and acid production by them.
conclusionsDue to the results obtained in this research, nanoliposomal curcumin had good antibacterial, anti-biofilm, and acid production inhibition properties. Maybe nanoliposomal curcumin can be used in oral and dental health products.
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