ArticlePediatric pulmonology2026
Peri and Neonatal Risk Factors and Structural Lung Abnormalities Predict Hypoxic Challenge Test Failure in Infants With Severe Bronchopulmonary Dysplasia.
Article in Pediatric pulmonology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
introductionInfants with severe bronchopulmonary dysplasia (BPD) are at increased risk of hypoxemia and often fail hypoxic challenge testing (HCT). The predictive value of clinical characteristics and structural lung abnormalities on HCT outcomes is unclear.
methodsThis prospective cohort study included preterm-born infants (≤ 32 weeks of gestation) with severe BPD enrolled in a standardized follow-up program. Perinatal and neonatal data were extracted from medical records. At 6 months corrected gestational age, structural lung abnormalities were quantified on chest CT using PRAGMA-BPD scoring. HCT was performed using a sealed body plethysmograph and failure was defined as inability to maintain oxygen saturation ≥ 85% for 20 min. Univariate and multivariable logistic regression analyses identified predictors of HCT failure.
resultsAmong 156 infants, 28.8% failed HCT. Of the perinatal and neonatal factors, patent ductus arteriosus (odds ratio 2.73, 95% confidence interval 1.29-6.14), pulmonary hypertension (2.57, 0.99-6.62), and longer duration of supplemental oxygen therapy (odds ratio per interquartile range increase [OR
conclusionDuration of supplemental oxygen therapy and structural lung abnormalities independently predict HCT failure, highlighting the clinical relevance of both structural and functional impairments in severe BPD.
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