Evidence map›Paper›PMID 41704018›Full record

Trial reportPhysiological reports2026

The effect of two remote exercise programs on cardiorespiratory fitness, cardiac function, and vascular health in patients with breast cancer.

Nathan R Weeldreyer, Charles C Ellison, Mckenzie B Mabalot, Cheyanne E Helms, Zachariah B Nealy, Zachary S Leicht, Antonio Abbate, Christiana M Brenin, Patrick M Dillon, Trish Millard and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nathan R WeeldreyerIntegrated Cardiovascular Exercise Physiology (iCARE) Laboratory, College of health Sciences, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-0314-7679
Charles C EllisonDepartment of Kinesiology, University of Virginia, Charlottesville, Virginia, USA.
Mckenzie B MabalotDepartment of Kinesiology, University of Virginia, Charlottesville, Virginia, USA.
Cheyanne E HelmsDepartment of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Zachariah B NealyDepartment of Medicine, Division of Cardiovascular Medicine, University of Virginia, Charlottesville, Virginia, USA.
Zachary S LeichtDepartment of Kinesiology, University of Virginia, Charlottesville, Virginia, USA.
Antonio AbbateDepartment of Medicine, Division of Cardiovascular Medicine, University of Virginia, Charlottesville, Virginia, USA.
Christiana M BreninDivision of Hematology/Oncology, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Patrick M DillonDivision of Hematology/Oncology, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Trish MillardDivision of Hematology/Oncology, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Rebecca A KrukowskiDepartment of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Jamie M ZoellnerDepartment of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Siddhartha S AngadiDepartment of Kinesiology, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-2932-7926

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Consumer-based meditation app, Calm, for treatment of sleep disturbance in hematological cancer patientsR01CA262041 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jennifer Lynne Huberty, Ruben A. Mesa · 2022 to 2026
$2.8M
NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA262041UVA Cancer Center (Cancer Center) P30CA044579UVA Imaging, and Informatics in Precision Immunomedicine (iPRIME) Initiative
6 · The paper itself

Abstract

Breast cancer is a common, survivable malignancy affecting women. With improved survival, the off-target effects of chemotherapy, such as a decline in cardiorespiratory fitness and worse cardiovascular outcomes, have been recognized. Exercise training may help mitigate these effects. In this study, patients with breast cancer (N = 24) scheduled to undergo chemotherapy were randomized to either remotely administered high-intensity interval training (HIIT) or moderate-intensity exercise (MOD) based on ACSM guidelines for cancer survivors. HIIT involved three weekly sessions using the 4 × 4 protocol at 85%-90% peak heart rate (PHR), while MOD consisted of 150 min per week at 70%-75% PHR. Exercise training began 1-2 weeks before chemotherapy and continued throughout treatment. Baseline testing was conducted prior to chemotherapy and follow-up testing 7-10 days after completion. Assessments included VO

Indexed as

Breast NeoplasmsCardiorespiratory FitnessExercise TherapyHigh-Intensity Interval TrainingAdultFemaleHeart RateHumansMiddle AgedOxygen ConsumptionVascular Healthcardio‐oncologycardiorespiratory fitnesscardiovascular diseaseexercise

Identifiers

PMID41704018
PMCPMC12914078

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.