Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
16 authors.
Takahiro MaenoLaboratory of Muscle and Meat Science, Department of Animal and Marine Bioresource Sciences, Research Faculty of Agriculture, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.ORCID 0009-0008-6629-3447
Tomoki UshijimaLaboratory of Muscle and Meat Science, Department of Animal and Marine Bioresource Sciences, Research Faculty of Agriculture, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.ORCID 0009-0009-9564-3503
Koichi OjimaMuscle Biology Research Unit, Division of Animal Products Research, Institute of Livestock and Grassland Science, NARO, Tsukuba, Japan.ORCID 0000-0002-5973-1073
Yohei OgawaLaboratory of Muscle and Meat Science, Department of Animal and Marine Bioresource Sciences, Research Faculty of Agriculture, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.ORCID 0009-0005-3810-589X
Sayuki HayashiLaboratory of Muscle and Meat Science, Department of Animal and Marine Bioresource Sciences, Research Faculty of Agriculture, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.ORCID 0009-0002-5732-0913
Hikaru ImakyureLaboratory of Muscle and Meat Science, Department of Animal and Marine Bioresource Sciences, Research Faculty of Agriculture, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.ORCID 0009-0005-0873-1005
Rika OsakiLaboratory of Muscle and Meat Science, Department of Animal and Marine Bioresource Sciences, Research Faculty of Agriculture, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.ORCID 0009-0001-2466-9142
Ryuki OyamaLaboratory of Muscle and Meat Science, Department of Animal and Marine Bioresource Sciences, Research Faculty of Agriculture, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.ORCID 0009-0001-9484-2983
Aoi OgawaLaboratory of Muscle and Meat Science, Department of Animal and Marine Bioresource Sciences, Research Faculty of Agriculture, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.ORCID 0009-0000-7572-6568
Akimasa TakanoLaboratory of Muscle and Meat Science, Department of Animal and Marine Bioresource Sciences, Research Faculty of Agriculture, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.ORCID 0009-0004-4798-5211
Kaoru MizoguchiLaboratory of Muscle and Meat Science, Department of Animal and Marine Bioresource Sciences, Research Faculty of Agriculture, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.ORCID 0009-0002-3979-6272
Issei YokoyamaLaboratory of Muscle and Meat Science, Department of Animal and Marine Bioresource Sciences, Research Faculty of Agriculture, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.ORCID 0000-0002-1998-0200
Yusuke KomiyaDepartment of Animal Science, School of Veterinary Medicine, Kitasato University, Towada, Japan.ORCID 0000-0003-3225-2491
Mako NakamuraLaboratory of Muscle and Meat Science, Department of Animal and Marine Bioresource Sciences, Research Faculty of Agriculture, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.ORCID 0000-0002-6129-7560
Ryuichi TatsumiLaboratory of Muscle and Meat Science, Department of Animal and Marine Bioresource Sciences, Research Faculty of Agriculture, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.ORCID 0000-0001-9223-0636
Takahiro SuzukiLaboratory of Muscle and Meat Science, Department of Animal and Marine Bioresource Sciences, Research Faculty of Agriculture, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan.ORCID 0000-0002-7949-5477
Funding
MEXT | Japan Society for the Promotion of Science (JSPS) 19K15959MEXT | Japan Society for the Promotion of Science (JSPS) 21H02347MEXT | Japan Society for the Promotion of Science (JSPS) 22J22522MEXT | Japan Society for the Promotion of Science (JSPS) 22K05955MEXT | Japan Society for the Promotion of Science (JSPS) 24K01911MEXT | Japan Society for the Promotion of Science (JSPS) 26660218the Ito Foundation Ken -114
6 · The paper itself
Abstract
Myoblasts autonomously govern myofiber-type specification of newly formed myotubes through autocrine-paracrine-dependent manners mediated by multipotent modulators. Netrin-1, which is particularly produced in myoblasts isolated from the extensor digitorum longus (EDL; fast-twitch myofiber-abundant) rather than the soleus (slow-twitch myofiber-abundant), and netrin-4, which is abundantly expressed during myogenic differentiation initiation, stimulate the synthesis of fast-type myosin heavy chain (MyHC) isoforms. However, the mechanisms by which netrin-1 and netrin-4 promote fast-twitch myotube formation remain unclear. Here, we investigated the roles of netrin receptors, uncoordinated-5 homologues (UNC5A, -B, -C, and -D), deleted in colorectal cancer (DCC), and the DCC paralog (neogenin) during myogenic differentiation, focusing on fast-twitch myotube formation. We confirmed that UNC5A, UNC5B, UNC5C, and neogenin synthesis patterns in EDL myoblasts showed no marked differences compared with those in soleus myoblasts. Notably, UNC5A knockdown severely inhibited fast-twitch myotube formation compared with other receptor knockdown treatments and significantly reduced the synthesis of fast-type MyHC isoforms. Additional treatment with recombinant netrin-1 or netrin-4 induced fast-type MyHC mRNA expression; however, this effect was suppressed by UNC5A knockdown. These findings revealed that UNC5A is involved in fast-twitch myotube formation via netrin ligands, highlighting an autonomous fast-type myofiber commitment system within myoblasts.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The uncoordinated-5 homologue A is a key receptor in netrin-ligand-mediated fast-twitch myotube formation in male mice. · full record | OpenQuestion