Evidence map›Paper›PMID 41703982›Full record

ArticleFEBS open bio2026

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer.

Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long and 1 more

Abstract read
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In one paragraph

Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Long Wai TsuiDivision of Life Science, Hong Kong University of Science & Technology, Hong Kong SAR.
Taobo HuScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Sweden.
Thomson Christian HuseinDivision of Life Science, Hong Kong University of Science & Technology, Hong Kong SAR.
Wai Hei ShekDivision of Life Science, Hong Kong University of Science & Technology, Hong Kong SAR.
Bingrong ChenDivision of Life Science, Hong Kong University of Science & Technology, Hong Kong SAR.
Depeng WangGrandOmics Inc, China.
Shu WangDepartment of Breast Surgery, Peking University People's Hospital, China.
Weichuan YuDepartment of Electronics and Computer Engineering, The Hong Kong University of Science & Technology, Hong Kong SAR.
Xiaodan FanDepartment of Statistics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR.
Mengping LongScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Sweden.
Toyotaka IshibashiDivision of Life Science, Hong Kong University of Science & Technology, Hong Kong SAR.ORCID https://orcid.org/0000-0001-8015-2319

Funding

Innovation and Technology Fund, the Hong Kong Innovation & Technology Commission MHP/033/20National Natural Science Foundation of China 32170548Research Grant Council Hong Kong C6036-21GF
6 · The paper itself

Abstract

ERαΔ7 is one of the most frequently observed splice variants of the ESR1 gene in breast cancer but its functions remain largely unknown. Here we report that ERαΔ7 predicted poor survival in luminal A type breast cancer from TCGA data. ERαΔ7 occurred more frequently in luminal type breast cancer, with expression inversely correlating with ESR1 expression. Functionally, ERαΔ7-expressing MCF-7 cells were found to have lower death rates at the expense of reduced growth and migration, while also being responsive to estrogen deprivation. Furthermore, molecular dynamics simulation showed that estradiol can bind to ERαΔ7. Our study indicated that ERαΔ7 might serve as a potential prognostic marker in Luminal A type breast cancer and has different functions from those of canonical ERα-expressing cells.

Indexed as

Breast NeoplasmsEstrogen Receptor alphaAlternative SplicingExonsFemaleGene Expression Regulation, NeoplasticHumansMCF-7 CellsPhenotypePrognosisRNA SplicingESR1 protein, humanEstrogen Receptor alphabreast cancerestrogen receptorsplicingtumor developmenttumor heterogeneity

Identifiers

PMID41703982
PMCPMC13327064

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.