Evidence map›Paper›PMID 41703897›Full record

ReviewMelanoma management2026

Insurance, race, and socioeconomic disparities in systemic therapy receipt for melanoma in the United States: a systematic review.

Shoshana Zhang, Rabecca-Kimberly Hernandez, Jordan Cheek, Rija Aziz, Imelda L Vetter, Adewole S Adamson

Abstract readReview
In one paragraph

Review in Melanoma management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shoshana ZhangDell Medical School, Austin, Texas, USA.ORCID 0000-0002-8135-0357
Rabecca-Kimberly HernandezDepartment of Internal Medicine, Dell Medical School, Austin, Texas, USA.ORCID 0000-0002-5656-2120
Jordan CheekDell Medical School, Austin, Texas, USA.
Rija AzizDepartment of Internal Medicine, Dell Medical School, Austin, Texas, USA.ORCID 0009-0001-7905-7725
Imelda L VetterDepartment of Medical Education, Dell Medical School, Austin, Texas, USA.ORCID 0000-0002-5402-0512
Adewole S AdamsonDepartment of Internal Medicine, Dell Medical School, Austin, Texas, USA.ORCID 0000-0002-1493-1776

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough evidence suggests disparities in melanoma treatment, no comprehensive summary exists on whether insurance type, race/ethnicity, or socioeconomic status consistently influence systemic therapy receipt. Understanding these associations may inform strategies to reduce inequities.

methodsWe conducted a systematic review of United States (US) based studies assessing systemic therapy receipt by insurance, socioeconomic status, and race/ethnicity. Searches of PubMed, Embase, and Web of Science were performed through July 10, 2025. Evidence quality was evaluated using the Oxford Center for Evidence-Based Medicine.

resultsOf 6,604 records screened and 223 full-texts reviewed, 30 retrospective cohort studies were included, encompassing 1,212,437 melanoma patients (1975-2021). Twenty-five studies stratified by insurance, 24 by socioeconomic status, and 21 by race/ethnicity. Insurance-based disparities were reported in 88% of studies, socioeconomic status-based disparities were reported in 75% of studies, and race/ethnicity- based disparities were reported in 38% of studies. Although 67% of studies used the National Cancer Database, findings were inconsistent across studies.

conclusionInsurance and socioeconomic status may be more consistent drivers of disparities in systemic therapy receipt for melanoma than race/ethnicity. However, variability in identifying disparities, even among studies using the same database, may complicate targeted interventions.

Indexed as

ethnicityhealth disparitiesimmunotherapyinsuranceMelanomaracesocioeconomic statussystemic therapy

Identifiers

PMID41703897
PMCPMC12928661

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.