ArticleThe American journal of psychiatry2026
Divergent Patterns of Genetic Overlap Between Severe Mental Disorders and Metabolic Markers.
Article in The American journal of psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Mapping genetic convergence across brain structure, mental health, and cardiometabolic disease.Communications medicine · 2026Article
- Association of Genetic Liability to Psychiatric Disorders with Peripheral Metabolic Dysregulation.medRxiv : the preprint server for health sciences · 2026Article
- Evidence for overlapping genetic architecture between lifestyle factors and severe mental disorders with different patterns across diagnoses.EBioMedicine · 2026Article
- Genetic influences on antidepressant side effects: a CYP2C19 gene variation and polygenic risk study in the Estonian Biobank.European journal of human genetics : EJHG · 2025Article
- Genome-wide association study for circulating metabolic traits in 619,372 individuals.medRxiv : the preprint server for health sciences · 2025Article
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Authors and funding
19 authors.
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Abstract
objectiveBipolar disorder, major depressive disorder (MDD), and schizophrenia are severe mental disorders and are each associated with poor cardiometabolic health. Mapping genetic relationships of these heritable disorders with blood markers of metabolic activity may uncover biological pathways underlying this important shared clinical feature.
methodsThe authors charted genetic overlap of the three disorders, type 2 diabetes, coronary artery disease, and body mass index (BMI) with 249 circulating metabolites through linkage disequilibrium score regression and bivariate Gaussian mixture modeling. Causal relationships and functionally annotated shared genetic variants were estimated, and enrichment across brain and body tissues was investigated.
resultsAll three disorders had extensive overlap with the metabolites. The pattern of genetic correlations was similar between MDD, type 2 diabetes, coronary artery disease, and BMI (Spearman's correlation r
conclusionsSevere mental disorders have strong associations with metabolites, and MDD has a distinctly different genetic relationship than bipolar disorder and schizophrenia do. The study findings suggest that metabolic pathways are involved in the development of severe mental disorders and can play a central role in disentangling disorder-specific etiologies. The "metabolic psychiatry" approach applied here has high potential to guide development of targeted interventions.
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