ArticleMolecular autism2026
Reduced inter-subject functional connectivity during movies in autism: replicability across cross-national fMRI datasets.
Article in Molecular autism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Naturalistic stimuli in neuroimaging studies of autism spectrum disorder: a systematic review.Frontiers in human neuroscience · 2026Pooled it
- Watching Together, Yet Feeling Apart: Interpersonal Neural Synchronization as a Marker of Symptom Severity in Children With Autism Spectrum Disorder During Naturalistic Viewing.Human brain mapping · 2026Article
- Pregistered movie-fMRI analyses reveal altered visual feature encoding in autism in pSTS.bioRxiv : the preprint server for biology · 2026Article
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13 authors.
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Abstract
backgroundAutism is a neurodevelopmental disorder characterized by repetitive behaviors and difficulties in social communication and interaction. Previous research has shown that these symptoms are linked to idiosyncratic behavioral and brain activity patterns while viewing natural social events in movies. This study aimed to investigate the replicability of brain activity idiosyncrasy in adult autistic individuals by comparing their inter-subject functional connectivity (ISFC) with that of neurotypical individuals.
methodsWe tested for ISFC differences between adult autistic and neurotypical groups using functional magnetic resonance imaging (fMRI) data from two independent datasets from Germany (Nneurotypical = 25, 7 Males, 18 Females; Nautism = 22, 12 Males, 10 Females) and Finland (Nneurotypical = 19, Nautism = 18; All males). Participants watched short movie stimuli, and pairwise ISFCs were computed across 273 brain regions. Group differences were evaluated using subject-wise permutation tests for each dataset.
resultsIn both datasets, the autistic group showed lower ISFCs compared to the neurotypical group, specifically between visual regions (e.g., occipital gyrus, cuneus) and parietal regions (e.g., superior and inferior parietal lobules), as well as between visual regions and frontal regions (e.g., inferior frontal gyrus, precentral gyrus). ISFC was higher in the Finnish autistic group in temporal regions associated with sound and speech processing. LIMITATIONS: Larger multi-site datasets using diverse analysis pipelines are needed to evaluate the robustness and replicability of current findings. They are also essential for evaluating the reliability of the subject-wise permutation method without explicit correction for multiple comparisons.
conclusionsThe study confirmed the replicability of reduced ISFCs in adult autistic individuals during naturalistic movie-watching, especially between visual and parietal/frontal brain regions. These findings reinforce the utility of ISFC and naturalistic movie-watching paradigm in studying neural connectivity alterations in autism.
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