Evidence map›Paper›PMID 41703609›Full record

SynthesisWorld journal of emergency surgery : WJES2026

Closed incision negative pressure wound therapy after emergency laparotomy: a systematic review and Meta-analysis of randomized controlled trials.

Jamal Ahmad, Mahmoud Diaa Hindawi, Ahmed Mohamed Hamdy, Alaa R Al-Ihribat, Omar Hammam Salloum, Mohammad Marrawani, Nada S Jibril, Mariam Elewidi, Hamdi Elbelkasi, Abd-Elfattah Kalmoush and 2 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of emergency surgery : WJES, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jamal AhmadFaculty of Medicine, Palestine Polytechnic University, Hebron, Palestine.ORCID https://orcid.org/0009-0008-3719-4538
Mahmoud Diaa HindawiFaculty of Medicine, Al-Azhar University, Cairo, Egypt.ORCID http://orcid.org/0009-0001-3085-6665
Ahmed Mohamed HamdyFaculty of Medicine, Zagazig University, Sharkia, Egypt.ORCID https://orcid.org/0009-0001-0372-3090
Alaa R Al-IhribatFaculty of Medicine, Palestine Polytechnic University, Hebron, Palestine.ORCID https://orcid.org/0009-0002-0401-4867
Omar Hammam SalloumFaculty of Medicine, Palestine Polytechnic University, Hebron, Palestine.ORCID http://orcid.org/0000-0002-0626-1928
Mohammad MarrawaniFaculty of Medicine, Palestine Polytechnic University, Hebron, Palestine.ORCID https://orcid.org/0009-0003-4392-3008
Nada S JibrilFaculty of Medicine, Menoufia University, Menoufia, Egypt.ORCID https://orcid.org/0009-0001-7917-6206
Mariam ElewidiFaculty of Medicine, Tanta University, Tanta, Egypt.ORCID https://orcid.org/0009-0005-8144-9962
Hamdi ElbelkasiMataryia Teaching Hospital (GOTHI), Cairo, Egypt.ORCID https://orcid.org/0000-0002-9556-6538
Abd-Elfattah KalmoushGeneral Surgery Department, Al-Azhar University, Cairo, Egypt.ORCID https://orcid.org/0000-0001-6927-223X
Andrew W KirkpatrickDepartments of Critical Care Medicine and Surgery, Foothills Medical Centre, Calgary, AB, Canada.ORCID https://orcid.org/0000-0002-1692-5919
Edward C T H TanDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands. Edward.tan@radboudumc.nl.ORCID https://orcid.org/0000-0002-9978-249X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEmergency laparotomy is associated with high rates of postoperative wound complications, contributing substantially to patient morbidity and healthcare burden. Closed incision negative pressure wound therapy (ciNPWT) has been proposed as a prophylactic strategy to reduce wound-related complications; however, its effectiveness in the emergency laparotomy setting remains uncertain. We evaluated whether ciNPWT reduces wound complications after emergency laparotomy compared with standard dressings.

methodsThis study is a systematic review and meta-analysis of randomized controlled trials (RCTs). Six databases and trial registries were systematically searched for RCTs from inception to October 10, 2025, with the search subsequently updated using automated database alerts (RSS) up to the time of manuscript submission.

resultsSix randomized controlled trials (1208 patients) were included. Compared with standard dressings, ciNPWT reduced overall wound morbidity (RR 0.49, 95% CI 0.38-0.62; I

conclusionIn adult patients undergoing emergency laparotomy with primary abdominal closure, ciNPWT significantly reduces key incision-related complications, particularly superficial SSI and wound dehiscence. Its clinical benefit appears confined to incision-level outcomes, with no effect on systemic or multifactorial postoperative endpoints. These findings support the selective use of ciNPWT in high-risk emergency laparotomy patients and highlight the need for standardized application protocols and longer-term outcome assessment.

Indexed as

LaparotomyNegative-Pressure Wound TherapyHumansRandomized Controlled Trials as TopicSurgical Wound InfectionAcute care surgeryEmergency laparotomyIncisional NPWTNegative pressure wound therapySurgical site infectionWound complications

Identifiers

PMID41703609
PMCPMC13014843

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.