Evidence map›Paper›PMID 41703595›Full record

ArticleActa obstetricia et gynecologica Scandinavica2026

Urinary alcohol and ethyl glucuronide as a screening tool for alcohol use in pregnancy: A multicenter prospective study.

Ciara A McCormick, Grace Mealy, Caroline Donaghy, Patricia Gordon, Elizabeth Dunn, Pauline Carroll, Alfonso Rodriguez-Herrera, Conrado M Cusnaider, William Ebbitt, Peter A McCormick and 1 more

Abstract readMulticenter Study
In one paragraph

Article in Acta obstetricia et gynecologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ciara A McCormickNational Maternity Hospital, Dublin, Ireland.ORCID 0000-0002-2142-1678
Grace MealyUCD Perinatal Research Centre, National Maternity Hospital, University College Dublin, Dublin, Ireland.
Caroline DonaghyNational Drug Treatment Centre, Dublin, Ireland.
Patricia GordonWexford General Hospital, Wexford, Ireland.
Elizabeth DunnUCD Perinatal Research Centre, National Maternity Hospital, University College Dublin, Dublin, Ireland.
Pauline CarrollSt Lukes's Hospital, Kilkenny, Ireland.
Alfonso Rodriguez-HerreraSt Lukes's Hospital, Kilkenny, Ireland.
Conrado M CusnaiderSt Lukes's Hospital, Kilkenny, Ireland.
William EbbittNational Drug Treatment Centre, Dublin, Ireland.
Peter A McCormickLiver Unit, St Vincent's University Hospital, Dublin, Ireland.
Fionnuala M McAuliffeNational Maternity Hospital, Dublin, Ireland.ORCID 0000-0002-3477-6494

Funding

National Drug Treatment Centre
6 · The paper itself

Abstract

introductionReports indicate that up to 60% of pregnant women in Ireland consume alcohol and Ireland may have the third highest prevalence of fetal alcohol syndrome in the world. We sought objective evidence of alcohol intake and the acceptability of urinary alcohol screening. MATERIAL AND

methodsThis was a multicenter, prospective study conducted at one urban and two semirural maternity units. Pregnant women at their first visit (≈13 weeks gestation) were invited to participate. Urinary samples were obtained with individual consent. Samples were anonymized and tested for alcohol and ethyl glucuronide at a central laboratory. The rate of sample positivity for ethanol (at a cut-off of 30 mg/dL) and ethyl glucuronide (at a cut-off of 500 ng/mL) was reported. The percentage of women consenting to testing was recorded. Results were compared with previous questionnaire or interview-based studies.

resultsOne thousand fifty-three urine samples were analyzed. None tested positive for ethanol but 4/1053 (0.38%) contained ethyl glucuronide. Three samples were positive in the urban cohort, 3/730 (0.41%) and 1/323 (0.31%) in the semirural centers. Consent was obtained in 96% and 98% in two semirural centers compared to 78% in the urban center (565/722 vs. 323/336. p < 0.01). Acceptability in the urban center depended on who requested consent and varied between 65% and 100% (p < 0.01). Consent to participate was significantly higher and detected alcohol use was significantly lower than in previous, interview or questionnaire-based studies.

conclusionsAlcohol intake appears to be much less common than previously estimated. The consent rates for urinary alcohol testing are high and are influenced by who is requesting consent.

Indexed as

Alcohol DrinkingEthanolGlucuronatesSubstance Abuse DetectionAdultBiomarkersFemaleHumansIrelandPregnancyProspective StudiesBiomarkersEthanolethyl glucuronideGlucuronatesalcoholethyl glucuronidefetal alcohol syndromepregnancyscreening

Identifiers

PMID41703595
PMCPMC13140590

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.