Evidence map›Paper›PMID 41703574›Full record

ArticleJournal of biomedical science2026

Intestinal epithelial Smad7 drives purine metabolic dysregulation and ileal inflammation.

Federica Laudisi, Mattia Alberto Serra, Lorenzo Tomassini, Massimo Claudio Fantini, Gustavo Monasterio, Ning He, Eduardo Maria Sommella, Angela Ortenzi, Giuseppe Sigismondo Sica, Francesca Zorzi and 8 more

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In one paragraph

Article in Journal of biomedical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Federica LaudisiDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Mattia Alberto SerraDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Lorenzo TomassiniDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Massimo Claudio FantiniDepartment of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
Gustavo MonasterioDivision of Immunology and Respiratory Medicine, Department of Medicine Solna (MedS), Karolinska Institute and University Hospital; SE-171 76 Stockholm, Sweden; Center for Molecular Medicine (CMM), Karolinska University Hospital, SE-171 64, Solna, Sweden.
Ning HeDivision of Immunology and Respiratory Medicine, Department of Medicine Solna (MedS), Karolinska Institute and University Hospital; SE-171 76 Stockholm, Sweden; Center for Molecular Medicine (CMM), Karolinska University Hospital, SE-171 64, Solna, Sweden.
Eduardo Maria SommellaDepartment of Pharmacy, University of Salerno, Fisciano, 84084, Salerno, Italy.
Angela OrtenziDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Giuseppe Sigismondo SicaDepartment of Surgery, University of Rome Tor Vergata, Rome, Italy.
Francesca ZorziGastroenterology Unit, Azienda Ospedaliera Policlinico Tor Vergata, Rome, Italy.
Teresa PacificoDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Ombretta MelaiuDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
Cristiano De StefanisBambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Valentina D'OriaBambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Carmine StolfiDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Ivan MonteleoneDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Eduardo Javier VillablancaDivision of Immunology and Respiratory Medicine, Department of Medicine Solna (MedS), Karolinska Institute and University Hospital; SE-171 76 Stockholm, Sweden; Center for Molecular Medicine (CMM), Karolinska University Hospital, SE-171 64, Solna, Sweden.
Giovanni MonteleoneDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy. gi.monteleone@med.uniroma2.it.

Funding

Ministero dell'Università e della Ricerca PNRR M4C2I1.3 PE6 project PE00000019 Heal ItaliaMinistero dell'Università e della Ricerca PRIN 2022JEBP88,
6 · The paper itself

Abstract

BACKGROUND AND

aimsDefects of the gut epithelial barrier and counter-regulatory mechanisms are a prerequisite for the onset of intestinal inflammation in patients with inflammatory bowel diseases (IBD). Elevated levels of Smad7, an inhibitor of TGF-β1, in both epithelial and immune cells have been associated with the pathological processes observed in IBD. We aim to determine the relevance of Smad7 expression in the epithelial compartment.

methodsWe generated mice overexpressing Smad7 in the gut epithelium (Smad7TgCre

resultsSmad7TgCre

conclusionOur data indicate that Smad7 overexpression in IECs is sufficient to promote ileal mucosal damage, which is linked to the impairment of purine metabolism.

Indexed as

Crohn DiseaseIleitisInflammationIntestinal MucosaPurinesSmad7 ProteinAnimalsHumansIleumIntestinal Barrier FunctionMiceMice, TransgenicpurinePurinesSmad7 ProteinSmad7 protein, mouseCrohn’s diseaseIBDMucosal immunityTGF-βUlcerative colitis

Identifiers

PMID41703574
PMCPMC12914907

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.