ArticleBMC musculoskeletal disorders2026
Non-cervical diffuse idiopathic skeletal hyperostosis is a risk factor for severe cervical spinal cord injury.
Article in BMC musculoskeletal disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDiffuse idiopathic skeletal hyperostosis (DISH) is a degenerative condition characterized by progressive ossification of anterior longitudinal ligaments, creating rigid spinal segments that act as lever arms susceptible to traumatic forces. The resulting fused segments restrict spinal flexibility and increase fracture instability compared to normal spine. While cervical DISH (c DISH) is known to be associated with increased paralysis severity and high mortality rates, the impact of DISH not extending to the cervical region (non-c DISH) on cervical spinal cord injury (SCI) severity remains unexplored. We investigated the relationship between non-c DISH and paralysis severity in cervical SCI patients.
methodsAmong 516 cervical SCI patients (2011–2023), 403 who underwent whole-spine CT and had classifiable ASIA impairment scales were included. DISH prevalence in thoracic, cervicothoracic, thoracolumbar, and whole-spine regions was examined. Relationships between DISH presence, age > 65 years, high-energy trauma, sex, cervical OPLL, and severe paralysis (ASIA grades A-B) were analyzed using ANOVA. Multivariate logistic regression explored associations between severe paralysis and c DISH/non-c DISH after Bonferroni correction.
resultsDISH prevalence was 21.1% (thoracic), 5.7% (cervicothoracic), 7.9% (thoracolumbar), and 2.2% (whole spine). Significant differences in ASIA impairment scale distribution were observed between DISH and non-DISH groups (P < 0.05). Multivariate analysis revealed significant associations between severe paralysis and DISH presence (OR 2.03, 95% CI 1.20–3.42) and male sex (OR 2.00, 95% CI 1.00-4.02). Both c DISH and non-c DISH were associated with severe paralysis compared to no DISH (c DISH: OR 4.56, 95% CI 2.09–9.96, P < 0.001; non-c DISH: OR 1.76, 95% CI 1.01–3.06, P < 0.05).
conclusionsThis study demonstrates that non-c DISH significantly increases the risk of severe cervical SCI, suggesting that thoracolumbar rigidity may biomechanically compromise cervical spine vulnerability during trauma. These findings have important clinical implications for risk assessment and management strategies in DISH patients sustaining cervical injuries.
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