ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]2026
Precision medicine in sepsis: reappraising glucocorticoid therapy through the lens of molecular endotypes.
Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Recent advances in screening, diagnosis, prognosis and personalized treatment of sepsis.European journal of microbiology & immunology · 2026Review
- From Variant Interpretation to Biomarker Translation: Multi-omics Integration in Inherited Neuromuscular Diseases.Human mutation · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a life-threatening organ dysfunction syndrome with high mortality. Due to the heterogeneity of its clinical manifestations and treatment responses, it has long faced great challenges in clinical management. In recent years, the progress of molecular biology and omics technology has promoted the application of precision medical strategies based on molecular endotypes in sepsis research, which has opened up a new way for individualized treatment. Glucocorticoids are commonly used drugs in sepsis treatment, but their efficacy and safety vary significantly among patients with different molecular endotypes. The traditional one-size-fits-all therapy has been difficult to meet the complex clinical needs. This review systematically summarizes molecular endotype classifications in sepsis. It explores glucocorticoid mechanisms across different endotypes and summarizes recent clinical and preclinical advances. The article aims to provide theoretical foundations and practical guidance for precision therapy in sepsis, ultimately promoting personalized medicine in this field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.