Evidence map›Paper›PMID 41703125›Full record

ArticleScientific reports2026

Functional analysis of major detoxification gene superfamilies driving flubendiamide resistance in South Indian Tuta absoluta field populations.

Muthu Lakshmi Bavithra Chandra Mohan, Murugan Marimuthu, Balasubramani Venkatasamy, Alagar Muthu, Priyanka Muguntharajan

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Muthu Lakshmi Bavithra Chandra MohanDepartment of Agricultural Entomology, Centre for Plant Protection Studies, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, 641003, India.
Murugan MarimuthuDepartment of Agricultural Entomology, Centre for Plant Protection Studies, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, 641003, India. muruganmarimuthu@tnau.ac.in.
Balasubramani VenkatasamyController of Examinations, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, 641003, India.
Alagar MuthuDepartment of Agricultural Entomology, Centre for Plant Protection Studies, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, 641003, India.
Priyanka MuguntharajanDepartment of Agricultural Entomology, Centre for Plant Protection Studies, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, 641003, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tomato pinworm Tuta absoluta (Meyrick), a major pest, has spread worldwide and caused substantial economic losses in tomato cultivation. Repeated insecticide use has resulted in widespread resistance, especially to the diamide insecticide flubendiamide. This study explored the molecular mechanisms underlying flubendiamide resistance in a field population of T. absoluta from South India, focusing on detoxification-related gene families, such as cytochrome P450 monooxygenases (CYP450s), glutathione S-transferases (GSTs), and carboxyl/choline esterases (CCEs). Phylogenetic analysis was performed using 26 gene sequences from T. absoluta and related lepidopteran species. Bioassays revealed that the Krishnagiri (KNG) population is highly resistant, and gene expression analysis was conducted on KNG and susceptible populations treated with sublethal LC

Indexed as

BenzamidesInsecticide ResistanceInsecticidesMothsSulfonesAnimalsCytochrome P-450 Enzyme SystemFluorocarbonsInactivation, MetabolicIndiaInsect ProteinsLarvaMolecular Docking SimulationPhthalimidesPhylogenyBenzamidesCytochrome P-450 Enzyme SystemflubendiamideFluorocarbonsInsecticidesInsect ProteinsPhthalimidesSulfonesCytochrome P450Flubendiamide resistanceGene expressionGlutathione S-transferaseMolecular dockingTuta absoluta

Identifiers

PMID41703125
PMCPMC13003024

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.