Evidence map›Paper›PMID 41702998›Full record

Trial reportScientific reports2026

Basic emotions reported by individuals with persistent physical symptoms receiving exposure therapy versus healthy lifestyle promotion in primary care.

Jonna Hybelius, Sandra Af Winklerfelt Hammarberg, Sigrid Salomonsson, Caroline Wachtler, Majken Epstein, Anna Olsson, Emma Strand, Lina Söderström Winter, Alice Ahnlund Hoffmann, Edward Spansk and 9 more

Erratum issued Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04942028 (Randomized Controlled Trial of Internet-delivered Exposure-based Treatment vs. Standardized Education for Distress Related to Somatic Symptoms in Primary Care), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04942028 nacompletednot on this map

Randomized Controlled Trial of Internet-delivered Exposure-based Treatment vs. Standardized Education for Distress Related to Somatic Symptoms in Primary Care

TypeinterventionalSponsorRegion StockholmRan2021 to 2025Enrolled161ConditionsSomatic Symptom and Related Disorders, Medically Unexplained Symptoms, Psychological Factors Affecting Other Medical ConditionsArmsExposure, Standardized education, Prolonged assessment
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Jonna HybeliusDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden. jonna.hybelius@ki.se.
Sandra Af Winklerfelt HammarbergDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Sigrid SalomonssonCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Caroline WachtlerDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Majken EpsteinLiljeholmen University Primary Health Care Center, Academic Primary Health Care Center, Region Stockholm, Stockholm, Sweden.
Anna OlssonLiljeholmen University Primary Health Care Center, Academic Primary Health Care Center, Region Stockholm, Stockholm, Sweden.
Emma StrandLiljeholmen University Primary Health Care Center, Academic Primary Health Care Center, Region Stockholm, Stockholm, Sweden.
Lina Söderström WinterLiljeholmen University Primary Health Care Center, Academic Primary Health Care Center, Region Stockholm, Stockholm, Sweden.
Alice Ahnlund HoffmannCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Edward SpanskMeliva Primary Health Care Center Kungshörnet, Uppsala, Sweden.
Tomas ÅkerlundLiljeholmen University Primary Health Care Center, Academic Primary Health Care Center, Region Stockholm, Stockholm, Sweden.
Daniel BjörkanderLiljeholmen University Primary Health Care Center, Academic Primary Health Care Center, Region Stockholm, Stockholm, Sweden.
Amanda KosicSchool of Law, Psychology and Social Work, Örebro University, Örebro, Sweden.
Gabriel ChahinLiljeholmen University Primary Health Care Center, Academic Primary Health Care Center, Region Stockholm, Stockholm, Sweden.
John WallertCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Eva Toth-PalDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Steven NordinDepartment of Psychology, Umeå University, Umeå, Sweden.
Michael WitthöftDepartment of Clinical Psychology and Psychotherapy, Ruhr University Bochum, Bochum, Germany.
Erland AxelssonDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The importance of fear has been emphasized in research and treatment focusing on persistent physical symptoms (PPS). Recognizing a broader range of emotions may inform theory and personalized care. This study aimed to examine what basic emotions individuals with PPS experience related to their physical symptoms, the correlations between such emotions and overall somatic symptom burden and disability, and whether emotions change with treatment. Analyses drew on data from a randomized controlled trial that compared internet-delivered exposure therapy with healthy lifestyle promotion for patients with PPS (n = 159), supplemented by data from age- and gender-matched healthy volunteers (n = 160). Participants self-reported emotions related to their physical symptoms. Mean differences were evaluated within a linear regression modeling framework. Compared with the healthy volunteers, PPS participants scored significantly higher on anger, disgust, fear, sadness, and shame, and lower on joy. Disgust, fear, sadness, and shame correlated significantly with somatic symptom burden; anger, fear, sadness, and shame with disability. All negatively valenced emotions reduced significantly in both interventions, without significant between-group effects. Joy increased significantly in exposure. These results highlight the potential relevance of diverse emotions in PPS. To facilitate personalized care, future work could evaluate the unique contribution of specific emotions to clinical outcomes.

Indexed as

EmotionsHealth PromotionHealthy LifestyleImplosive TherapyAdultFearFemaleHumansMaleMiddle AgedPrimary Health CareSelf ReportEmotionsExposure therapyHealthy lifestyle promotionInternet-deliveredPersistent physical symptomsPrimary care

Identifiers

PMID41702998
PMCPMC12920773

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.