Evidence map›Paper›PMID 41702949›Full record

ArticleNature communications2026

Phenotype of circulating tumor-reactive T cells predicts immune checkpoint inhibitor response in non-small cell lung cancer.

Katsuhiro Ito, Kei Iida, Tomoko Hirano, Merrin Man Long Leong, Kenji Morii, Toshi Menju, Hiroshi Date, Hiroaki Ozasa, Hironori Yoshida, Toyohiro Hirai and 7 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Towards liquid biopsy-based analysis of antitumour immunity.Nature reviews. Clinical oncology · 2026
    Review
  2. Immune decoding from a multi-omics perspective: Redefining pancreatic cancer tumor microenvironment.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Katsuhiro ItoDepartment of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-6322-9190
Kei IidaInfomatics Platform, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0001-7130-8705
Tomoko HiranoDepartment of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0003-1399-1686
Merrin Man Long LeongDepartment of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0003-4753-2285
Kenji MoriiDepartment of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Toshi MenjuDepartment of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hiroshi DateDepartment of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hiroaki OzasaDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hironori YoshidaDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Toyohiro HiraiDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Shusuke KawashimaDepartment of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan.
Kazuhiro AoyamaDepartment of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan.ORCID http://orcid.org/0009-0008-7078-5380
Yuka SaekiDepartment of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan.
Takashi InozumeDepartment of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan.
Takashi KobayashiDepartment of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0003-1069-2816
Kenji ChamotoDepartment of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. chamoto.kenji.4w@kyoto-u.ac.jp.ORCID http://orcid.org/0000-0001-8625-3612
Tomonori YaguchiDepartment of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. yaguchi.tomonori.4m@kyoto-u.ac.jp.ORCID http://orcid.org/0000-0002-2904-9030

Funding

Japan Agency for Medical Research and Development (AMED) JP23zf0127004, JP24ama221330MEXT | Japan Society for the Promotion of Science (JSPS) JP24K02325, JP21H03087, JP24K22068
6 · The paper itself

Abstract

Peripheral blood (PB) is a source of tumor-infiltrating tumor-reactive T cells (TR-T). Circulating TR-Ts (cTR-T) in PB are expected to contribute to the efficacy of immune checkpoint inhibitors (ICIs), but their phenotype remains poorly understood. Here we analyse paired tumor-infiltrating and peripheral CD8

Indexed as

Carcinoma, Non-Small-Cell LungImmune Checkpoint InhibitorsLung NeoplasmsLymphocytes, Tumor-InfiltratingAgedAnimalsCD8-Positive T-LymphocytesFemaleHumansMaleMiceMiddle AgedPhenotypeReceptors, Antigen, T-CellSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisImmune Checkpoint InhibitorsReceptors, Antigen, T-Cell

Identifiers

PMID41702949
PMCPMC13022356

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.