Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed.
TruncatingbioRxiv : the preprint server for biology · 2026
Article
4 · The record
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Shuang LuInstitute of Translational Medicine, The First Hospital, Jilin University, Changchun, China.
Clémence MessmerCell Signaling and Cancer Research Unit, Maisonneuve-Rosemont Hospital Research Center, CIUSSS de l'Est-de-l'Ȋle de Montréal, Montréal, QC, Canada.
Yakun PangDepartment of Cell Systems and Anatomy, Mays Cancer Center, UT Health Science Center San Antonio, San Antonio, TX, USA.
Soumi BiswasDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.
Moustafa KhalilCell Signaling and Cancer Research Unit, Maisonneuve-Rosemont Hospital Research Center, CIUSSS de l'Est-de-l'Ȋle de Montréal, Montréal, QC, Canada.
Peng ZhangDepartment of Cell Systems and Anatomy, Mays Cancer Center, UT Health Science Center San Antonio, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-3394-6922
Rima TulaihaDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Toshio KitamuraInstitute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan.ORCID http://orcid.org/0000-0001-7855-1767
Shannon M LauberthDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4131-8536
M Andres BlancoDepartment of Biomedical Sciences, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4404-2301
Feng-Chun YangDepartment of Cell Systems and Anatomy, Mays Cancer Center, UT Health Science Center San Antonio, San Antonio, TX, USA.ORCID http://orcid.org/0000-0001-8524-4095
El Bachir AffarCell Signaling and Cancer Research Unit, Maisonneuve-Rosemont Hospital Research Center, CIUSSS de l'Est-de-l'Ȋle de Montréal, Montréal, QC, Canada.ORCID http://orcid.org/0000-0002-6374-3683
Zibo ZhaoDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-1089-2375
Lu WangDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. lu.wang1@northwestern.edu.ORCID http://orcid.org/0000-0003-0441-0747
Tatiana G KutateladzeDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA. tatiana.kutateladze@cuanschutz.edu.ORCID http://orcid.org/0000-0001-7375-6990
Funding
Transcriptional Control of Neuroinflammation in Alzheimer's DiseaseR01AG072562 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAI, DONGMING, ZHOU, MING-MING · 2021 to 2025
$4.2M
Mechanism of BET Proteins in Th17 Cell DifferentiationR01AI124465 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ZHOU, MING-MING · 2016 to 2020
$2.9M
Mechanism of Transcriptional Regulation of Th2 Cell DevelopmentR01AI177461 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Kalung Cheung, Ming-Ming Zhou · 2023 to 2026
$2.7M
Role of BAP1/ASXL3 complex in transcriptional regulation and development-ADMIN SUPPL for EquipmentR35GM146979 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Lu Wang · 2022 to 2026
$2.2M
NIAID NIH HHS R01 AI124465NIAID NIH HHS R01 AI177461NIA NIH HHS R01 AG072562NIGMS NIH HHS R35 GM146979U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA252707U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM157928U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG067664
6 · The paper itself
Abstract
ASXL1 is a well-established driver of a wide range of cancers. Here, we identify a high level of genetic correlation between ASXL1 and the major transcriptional activator BRD4 in cancer cells and characterize the molecular mechanism underlying this correlation. Structural and biochemical data show the formation of a tight complex between the extraterminal domain of BRD4 and the BRD4-binding motif of ASXL1. ChIP-seq analysis of mutated ASXL1 that cannot bind BRD4 demonstrates that the recruitment of BRD4 to the ASXL1 genomic targets depends on this interaction. We find that the cancer-related truncated variants comprising residues 1-645 and 1-591 of ASXL1 (ASXL1
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Recruitment of BRD4 to the ASXL1 genomic targets depends on the extra-terminal domain of BRD4. · full record | OpenQuestion