Evidence map›Paper›PMID 41702795›Full record

ArticleOral surgery, oral medicine, oral pathology and oral radiology2026

Black bone MRI morphometry for mandibular cortical bone measurement in head and neck cancer patients: prospective method comparison with CT.

Lisanne V van Dijk, Juan Ventura, Kareem A Wahid, Lin L Zhu, Brigid A McDonald, Sara Ahmed, Keith L Sanders, Sonja M Stieb, Lance McCoy, Christina S Sharafi and 20 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral surgery, oral medicine, oral pathology and oral radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Radiographic classification of mandibular osteoradionecrosis: A blinded prospective multi-disciplinary interobserver diagnostic performance study.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Lisanne V van DijkDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; University Medical Center Groningen, University of Groningen, Groningen, NL, USA.
Juan VenturaDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; John Sealy School of Medicine, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Kareem A WahidDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lin L ZhuDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Harvard Radiation Oncology Program, Boston, MA, USA.
Brigid A McDonaldDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sara AhmedDepartment of Radiation Oncology, Baylor College of Medicine, Houston, TX, USA.
Keith L SandersDepartment of Bioinformatics and Systems Medicine, McWilliams School of Biomedical Informatics, Houston, TX, USA.
Sonja M StiebDepartment of Radio-Oncology, KSA Cantonal Hospital Aarau, Aarau, Switzerland.
Lance McCoyDepartment of Medicine, Morehouse School of Medicine, Atlanta, GA, USA.
Christina S SharafiCollege of Osteopathic Medicine, NOVA Southeastern University, Fort Lauderdale, FL, USA.
Kathryn E PrestonDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; College of Pharmacy, University of Houston, Houston, TX, USA.
Natalie A WestDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, USA.
Sarah MirbahaeddinDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Dina M El-HabashyTransitional Year Program, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA.
Travis SalzilloDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Samuel MulderDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, USA.
Joly FahimDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Aubryane DeArmasDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Mona ArbabDepartment of Radiation Oncology, UT Southwestern, Dallas, TX USA.
Yao DingDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jihong WangDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Bastien RigaudDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Anando SenSchool of Healthcare and Nursing Sciences, Northumbria University, Newcastle upon Tyne, England.
Mark ChambersDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Katherine A HutchesonDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kristy K BrockThe University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, USA; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Program for Image-Guided Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Abdallah S R MohamedDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Radiation Oncology, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.
Stephen Y LaiDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, USA; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA; Program for Image-Guided Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Clifton D FullerDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, USA; Program for Image-Guided Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: cdfuller@mdanderson.org.
MRI-Radiotherapy Development Cooperative

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Targeting the p53 pathway for reversal of oral premalignancyP50CA097007 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MILLS, GORDON B. · 2002 to 2012
$26.1M
Project 3: OPC-RADP01CA285249 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Katherine Arnold Hutcheson · 2024 to 2026
$9.4M
Development of functional magnetic resonance imaging-guided adaptive radiotherapy for head and neck cancer patients using novel MR-Linac deviceR01DE028290 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHRISTODOULEAS, JOHN PAUL, FULLER, CLIFTON DAVID · 2019 to 2023
$4.3M
NRSA Training CoreTL1TR003169 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHANDRA, JOYA, FROST, JEFFREY A. · 2019 to 2023
$3.7M
Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Establish Objective Clinical Outcome Measures for Mandibular OsteoradionecrosisR01DE025248 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LAI, STEPHEN Y · 2016 to 2020
$2.9M
Image Guided Cancer Therapy Training ProgramT32CA261856 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Kristy Brock, Clifton David Fuller · 2022 to 2026
$1.2M
CTSA Predoctoral T32 at the University of Texas Health Science Center at HoustonT32TR004905 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Joya Chandra, Jeffrey A. Frost · 2024 to 2026
$811k
imaging Radiation-Associated Dysphagia (iRAD)R01CA218148 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI FULLER, CLIFTON DAVID, HUTCHESON, KATHERINE ARNOLD · 2017 to 2019
$810k
Fellow and Resident Radiation Oncology iNtensive Training in Imaging and Informatics to Empower Research Careers (FRONTI2ER)R25EB025787 · NIBIB · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DAS, PRAJNAN, FULLER, CLIFTON DAVID · 2018 to 2022
$535k
Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Establish Objective Clinical Outcome Measures for Mandibular OsteoradionecrosisR56DE025248 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LAI, STEPHEN Y · 2015 to 2015
$470k
Diffusion-Weighted Imaging-Based Adaptive Replanning for the MR-LinacF31DE029093 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MCDONALD, BRIGID ANNE · 2019 to 2021
$91k
NCATS NIH HHS T32 TR004905NCATS NIH HHS TL1 TR003169NCI NIH HHS P01 CA285249NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA097007NCI NIH HHS R01 CA218148NCI NIH HHS T32 CA261856NIBIB NIH HHS R25 EB025787NIDCR NIH HHS F31 DE029093NIDCR NIH HHS F31 DE031502NIDCR NIH HHS R01 DE025248NIDCR NIH HHS R01 DE028290NIDCR NIH HHS R56 DE025248
6 · The paper itself

Abstract

objectivesDetermine the utility of low-flip angle "black bone" magnetic resonance imaging (MRI) for cortical mandibular bone assessment compared to computed tomography (CT).

methodsQuantification of cortical mandibular bone width was performed per Hamada et al. at 15 cross-sectional interdentium locations on pretreatment black bone MRI and CT for 15 oropharyngeal cancer patients, with interobserver analyses on a subset of three patients by 11 observers. CT and MRI measurements were compared using Bland-Altman analysis, Lin's concordance, and Deming regression; interobserver variability was assessed with absolute variance and intraclass correlation coefficient (ICC).

resultsBland Altman and Deming regression analyses showed CT and black bone MRI measurements were comparable within ±0.85mm limits of agreement, and systematically smaller for MRI. ICC (0.60[0.52;0.67]) showed moderate equivalence between modalities. The average absolute variance between the observers was similar on CT (1.13±0.06mm) and MRI (1.15±0.06mm). ICC analysis showed that measurement consistency was significantly higher (p<0.001) for black bone MRI (0.43[0.32;0.56]) than CT (0.22[0.13;0.35]); nonetheless, ICC was poor for both modalities.

conclusionBlack bone MRI is a viable alternative to CT for assessing mandibular cortical bone and early detection of anatomical changes like osteoradionecrosis. Both modalities showed similar interobserver variability, which may be reduced through (semi)automated measurement.

Indexed as

Cortical BoneHead and Neck NeoplasmsMagnetic Resonance ImagingMandibleTomography, X-Ray ComputedAgedFemaleHumansMaleMiddle AgedObserver VariationProspective Studies

Identifiers

PMID41702795
PMCPMC12962360

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.