Evidence map›Paper›PMID 41702662›Full record

ArticleBMJ open2026

STRATUM-OS: first step in the development and validation of the STRATUM tool based on multimodal data processing to assist surgery in patients affected by intra-axial brain tumours - observational study protocol.

Himar Fabelo, Yolanda Ramallo-Fariña, Jesús Morera, Juan F Piñeiro, Alfonso Lagares, Luis Jiménez-Roldán, Gustav Burström, Miguel A García-Bello, Lidia García-Pérez, Rebeca Falero and 15 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07036783 (Multimodal Data Collection for the Development and Validation of the STRATUM Tool to Assist Surgery in Patients Affected by Brain Tumours), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07036783 not yet recruitingnot on this map

Multimodal Data Collection for the Development and Validation of the STRATUM Tool to Assist Surgery in Patients Affected by Brain Tumours: Observational Study

Typeobservational_patient_registrySponsorFundación Canaria Instituto de Investigación Sanitaria de CanariasRan2025 to 2027Enrolled320ConditionsBrain (Nervous System) Cancers, Brain Tumor, Primary
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Himar FabeloFundación Canaria Instituto de Investigación Sanitaria de Canarias, Las Palmas de Gran Canaria, Las Palmas, Spain hfabelo@iuma.ulpgc.es stratum@iuma.ulpgc.es.ORCID http://orcid.org/0000-0002-9794-490X
Yolanda Ramallo-FariñaFundación Canaria Instituto de Investigación Sanitaria de Canarias, Las Palmas de Gran Canaria, Las Palmas, Spain.
Jesús MoreraDepartment of Neurosurgery, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain.
Juan F PiñeiroDepartment of Neurosurgery, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain.
Alfonso LagaresDepartment of Neurosurgery, Hospital Universitario 12 de Octubre, Madrid, Community of Madrid, Spain.
Luis Jiménez-RoldánDepartment of Neurosurgery, Hospital Universitario 12 de Octubre, Madrid, Community of Madrid, Spain.
Gustav BurströmDepartment of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
Miguel A García-BelloFundación Canaria Instituto de Investigación Sanitaria de Canarias, Las Palmas de Gran Canaria, Las Palmas, Spain.
Lidia García-PérezFundación Canaria Instituto de Investigación Sanitaria de Canarias, Las Palmas de Gran Canaria, Las Palmas, Spain.ORCID http://orcid.org/0000-0002-5626-8116
Rebeca FaleroDepartment of Radiology, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain.
Marta GonzálezDepartment of Pathological Anatomy, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain.
Sebastián DuqueDepartment of Radiology, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain.
Consuelo Rodriguez-JimenezClinical Trials Unit, Pharmacology Department, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
María HernándezDepartment of Neurosurgery, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain.
Julio J Delgado-SánchezDepartment of Pathological Anatomy, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain.
Ana B ParedesDepartment of Pathological Anatomy, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain.
Guillermo HernándezDepartment of Radiology, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain.
Pedro PonceDepartment of Radiology, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain.
Raquel LeónInstitute for Applied Microelectronics, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Las Palmas, Spain.
Jesús M González-MartínResearch Unit, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain.
Francisco Rodríguez-EsparragónResearch Unit, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain.
Gustavo M CallicóInstitute for Applied Microelectronics, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Las Palmas, Spain.
Ana M WägnerInstituto de Investigación Sanitaria de Canarias (IISC), Las Palmas de Gran Canaria, Las Palmas, Spain.
Bernardino ClavoFundación Canaria Instituto de Investigación Sanitaria de Canarias, Las Palmas de Gran Canaria, Las Palmas, Spain.
STRATUM Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIntegrated digital diagnostics can support complex surgeries in many anatomic sites, and brain tumour surgery represents one of the most complex cases. Neurosurgeons face several challenges during brain tumour surgeries, such as differentiating critical tissue from brain tumour margins. To overcome these challenges, the STRATUM project will develop a 3D decision support tool for brain surgery guidance and diagnostics based on multimodal data processing, including hyperspectral imaging, integrated as a point-of-care computing tool in neurosurgical workflows. This paper reports the protocol for the development and technical validation of the STRATUM tool. METHODS AND ANALYSIS: This international multicentre, prospective, open, observational cohort study, STRATUM-OS (study: 28 months, pre-recruitment: 2 months, recruitment: 20 months, follow-up: 6 months), with no control group, will collect data from 320 patients undergoing standard neurosurgical procedures to: (1) develop and technically validate the STRATUM tool and (2) collect the outcome measures for comparing the standard procedure versus the standard procedure plus the use of the STRATUM tool during surgery in a subsequent historically controlled non-randomised clinical trial. ETHICS AND DISSEMINATION: The protocol was approved by the participant ethics committees. Results will be disseminated in scientific conferences and peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT07036783.

Indexed as

Brain NeoplasmsNeurosurgical ProceduresSurgery, Computer-AssistedHumansImaging, Three-DimensionalMulticenter Studies as TopicObservational Studies as TopicProspective StudiesResearch DesignArtificial IntelligenceNeurosurgeryObservational Study

Identifiers

PMID41702662
PMCPMC12918683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.