ArticleACS chemical neuroscience2026
Anisosmotic Modulation of Mutant Huntingtin Aggregation vis-a-vis HSP70 Induction─Implications for Aging, Hypo-Hydration, and Neurodegeneration.
Article in ACS chemical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Suboptimal cell hydration is a significant risk factor for age-related deterioration and disease vulnerability. Herein, we use a Huntington disease cell model to evaluate osmolarity-dependent modulation of (1) aggregation of polyQ-expanded mutant Huntingtin-EGFP reporter protein as a readout for structurally dynamic disease proteins versus (2) induction of HSP70 chaperone to report on stress-induced lability of folded proteins. Cell impermeant alkali-metal salts and polyethylene glycols were added to cell media to osmotically dehydrate cells for crowding, whereas water was added to swell cells for macromolecular dispersion. Cell image and biochemical analyses show that addition of sodium chloride and other alkali-metal salts to cell media promoted aggregation of mHTT
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