Evidence map›Paper›PMID 41702436›Full record

ArticleJournal of applied toxicology : JAT2026

Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm MicroRNA Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring.

Makiko Ito, Tetsushi Hirano, Sarika Nunobiki, Ayano Yoshimoto, Yukako Hara, Yuya Ishida, Sakura Yonoichi, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied toxicology : JAT, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Makiko ItoLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan.
Tetsushi HiranoFaculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan.ORCID 0000-0003-1516-4684
Sarika NunobikiLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan.
Ayano YoshimotoLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan.
Yukako HaraLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan.
Yuya IshidaLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan.
Sakura YonoichiLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan.
Youhei MantaniLaboratory of Histophysiology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan.
Toshifumi YokoyamaLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan.
Yoshiaki TabuchiFaculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan.ORCID 0000-0002-6007-6176
Yoshinori IkenakaLaboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Nobuhiko HoshiLaboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan.

Funding

Act Beyond TrustEnvironmental Restoration and Conservation Agency JPMEERF20245RA1Firstbank of Toyama Scholarship Foundation Research GrantJapan Society for the Promotion of Science 22K17342Japan Society for the Promotion of Science 25K02865Japan Society for the Promotion of Science 25K03271Japan Society for the Promotion of Science JP21K19846Japan Society for the Promotion of Science JP22H03750Japan Society for the Promotion of Science JP22K18425Japan Society for the Promotion of Science JP23H00512Japan Society for the Promotion of Science JP24K22204Kato Memorial Bioscience FoundationNakajima FoundationNihon Seimei FoundationSumitomo FoundationTriodos Foundation
6 · The paper itself

Abstract

Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown. The main purpose of this study was to examine the neurobehavioral effects on offspring mice resulting from paternal exposure to an NN, clothianidin (CLO). We also investigated microRNA (miRNA) expression in sperm-which plays an important role in epigenetics-to explore the involvement of sperm miRNAs in the paternal effects of CLO. Male mice were exposed to a no-observed-adverse-effect level dose of CLO (50 mg·kg

Indexed as

GuanidinesInsecticidesLocomotionMicroRNAsNeonicotinoidsPaternal ExposureSpermatozoaThiazolesAnimalsFemaleHippocampusMaleMicePregnancyclothianidinGuanidinesInsecticidesMicroRNAsNeonicotinoidsThiazoleshippocampusintergenerational effectmicroRNAneonicotinoidpaternal exposure

Identifiers

PMID41702436
PMCPMC13432759

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.